CAS 141626-36-0: Dronedarone

Description: Dronedarone is an antiarrhythmic medication primarily used to manage atrial fibrillation and atrial flutter. It is a derivative of amiodarone, designed to provide similar therapeutic effects with a reduced side effect profile. Dronedarone is characterized by its ability to prolong the action potential duration and refractory period in cardiac tissues, which helps to stabilize heart rhythm. Chemically, it is classified as a benzofuran derivative and contains multiple functional groups, including a carbonyl and an ether. Its molecular structure contributes to its pharmacological properties, allowing it to block various ion channels, including potassium, sodium, and calcium channels, as well as exhibiting beta-adrenergic antagonism. Dronedarone is typically administered orally and has a relatively short half-life compared to amiodarone, which may influence dosing regimens. It is important to note that while dronedarone is effective in rhythm control, it is contraindicated in patients with severe heart failure or those with a history of significant liver dysfunction due to potential adverse effects.

Formula: C₃₁H₄₄N₂O₅S

InChI: InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3

InChI key: InChIKey=ZQTNQVWKHCQYLQ-UHFFFAOYSA-N

SMILES: O=C(C1=CC=C(OCCCN(CCCC)CCCC)C=C1)C=2C=3C=C(C=CC3OC2CCCC)NS(=O)(=O)C

Synonyms:

• Methanesulfonamide, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-
• Multaq
• N-(2-Butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide
• N-(2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide
• N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide
• N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzo[b]furan-5-yl]methanesulfonamide
• N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzofuran-5-yl]methanesulfonamide
• Sr 33589
• Sr 33589B
• Unii-Jqz1L091Y2
• Dronedarone

Dronedarone Hydrochloride

CAS: 141625-93-6 141626-36-0

• Formula: C₃₁H₄₄N₂O₅S·HCl
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 593.22

Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-

CAS: 141626-36-0

• Formula: C₃₁H₄₄N₂O₅S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 556.7564599999998

Dronedarone

CAS: 141626-36-0

• Purity: 99.58%
• Molecular weight: 556.76g/mol

N-(2-Butyl-3-(4-(3-(Dibutylamino)Propoxy)Benzoyl)Benzofuran-5-Yl)Methanesulfonamide

CAS: 141626-36-0

• Purity: 98%
• Molecular weight: 556.76g/mol

Dronedarone

CAS: 141626-36-0

Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for …

• Formula: C₃₁H₄₄N₂O₅S
• Purity: 98.85% - 99.58%
• Color and Shape: Solid
• Molecular weight: 556.76

Dronedarone-d9

CAS: 141626-36-0

• Formula: C₃₁D₉H₃₅N₂O₅S
• Color and Shape: Neat
• Molecular weight: 565.812

Dronedarone

CAS: 141626-36-0

Dronedarone is a cardiac antiarrhythmic drug that is used to treat atrial fibrillation and maintain …

• Formula: C₃₁H₄₄N₂O₅S
• Purity: Min. 95%
• Molecular weight: 556.76 g/mol