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CAS 141626-36-0

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Dronedarone

Description:
Dronedarone is an antiarrhythmic medication primarily used to manage atrial fibrillation and atrial flutter. It is a derivative of amiodarone, designed to provide similar therapeutic effects with a reduced side effect profile. Dronedarone is characterized by its ability to prolong the action potential duration and refractory period in cardiac tissues, which helps to stabilize heart rhythm. Chemically, it is classified as a benzofuran derivative and contains multiple functional groups, including a carbonyl and an ether. Its molecular structure contributes to its pharmacological properties, allowing it to block various ion channels, including potassium, sodium, and calcium channels, as well as exhibiting beta-adrenergic antagonism. Dronedarone is typically administered orally and has a relatively short half-life compared to amiodarone, which may influence dosing regimens. It is important to note that while dronedarone is effective in rhythm control, it is contraindicated in patients with severe heart failure or those with a history of significant liver dysfunction due to potential adverse effects.
Formula:C31H44N2O5S
InChI:InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
InChI key:InChIKey=ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
SMILES:C(=O)(C=1C=2C(OC1CCCC)=CC=C(NS(C)(=O)=O)C2)C3=CC=C(OCCCN(CCCC)CCCC)C=C3
Synonyms:
  • Methanesulfonamide, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-
  • Multaq
  • N-(2-Butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide
  • N-(2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide
  • N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide
  • N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzo[b]furan-5-yl]methanesulfonamide
  • N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzofuran-5-yl]methanesulfonamide
  • Sr 33589
  • Sr 33589B
  • Unii-Jqz1L091Y2
  • Dronedarone
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