CAS 1416696-44-0

2-Oxoclopidogrel

Description:

2-Oxoclopidogrel, identified by its CAS number 1416696-44-0, is a chemical compound that serves as a metabolite of the antiplatelet drug clopidogrel. It is characterized by its role in inhibiting platelet aggregation, which is crucial for preventing thrombotic events such as heart attacks and strokes. The compound features a thienopyridine structure, which is essential for its pharmacological activity. As a prodrug, clopidogrel is metabolized in the liver to form 2-oxoclopidogrel, which then exerts its therapeutic effects. The compound is typically studied for its pharmacokinetics, efficacy, and safety profile in various clinical settings. Its solubility, stability, and interaction with biological systems are important characteristics that influence its therapeutic use. Additionally, understanding the metabolic pathways and the role of 2-oxoclopidogrel in the overall pharmacodynamics of clopidogrel is crucial for optimizing treatment strategies in patients at risk of cardiovascular events.

Formula: C₁₆H₁₆ClNO₃S

InChI: InChI=1S/C16H16ClNO3S/c1-21-16(20)15(11-4-2-3-5-12(11)17)18-7-6-13-10(9-18)8-14(19)22-13/h2-5,8,13,15H,6-7,9H2,1H3/t13-,15-/m0/s1

InChI key: InChIKey=JBSAZVIMJUOBNB-ZFWWWQNUSA-N

SMILES: [C@H](C(OC)=O)(N1CC=2[C@](CC1)(SC(=O)C2)[H])C3=C(Cl)C=CC=C3

Synonyms:

• Copidogrel oxide
• 2-Oxoclopidogrel
• (7aS,2′S)-2-Oxoclopidogrel
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-, methyl ester, (αS,7aS)-

(7aS, 2’S)-2-Oxo-Clopidogrel

CAS: 1416696-44-0

Formula: C₁₆H₁₆ClNO₃S

Molecular weight: 337.82

Ref: 4Z-C-13100

(4S)-2-Oxoclopidogrel

Controlled Product

CAS: 1416696-44-0

Applications (4S)-2-Oxoclopidogrel is an essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)

Formula: C₁₆H₁₆ClNO₃S

Color and Shape: Neat

Molecular weight: 337.821

Ref: TR-O992100

Becondogrel

CAS: 1416696-44-0

Becondogrel (2-Oxoclopidogrel) is a metabolite of Clopidogrel. It irreversibly inhibits the P2Y12 receptor, thereby preventing platelet aggregation and thrombosis.

Formula: C₁₆H₁₆ClNO₃S

Color and Shape: Solid

Molecular weight: 337.821

Ref: TM-T206145