CAS 14171-67-6

CLOMIPRAMINE N-OXIDE

Description:

Clomipramine N-oxide is a chemical compound derived from clomipramine, a tricyclic antidepressant. It is characterized by its molecular structure, which includes a nitrogen atom that is oxidized, resulting in the formation of an N-oxide. This modification can influence its pharmacological properties compared to its parent compound. Clomipramine N-oxide is typically a white to off-white solid and is soluble in organic solvents. It is primarily studied for its potential effects on neurotransmitter systems, particularly in relation to serotonin and norepinephrine reuptake inhibition. The compound may exhibit different biological activities, including antidepressant and anxiolytic effects, although its specific therapeutic applications are less well-documented than those of clomipramine itself. As with many chemical substances, safety and handling precautions are essential, as it may pose risks if not managed properly. Overall, clomipramine N-oxide represents an interesting area of research within the field of psychopharmacology.

Formula: C₁₉H₂₃ClN₂O

InChI: InChI=1/C19H23ClN2O/c1-22(2,23)13-5-12-21-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)21/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3

SMILES: CN(=O)(C)CCCN1c2ccccc2CCc2ccc(cc12)Cl

Synonyms:

• 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine N-Oxide

5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, N-oxide

CAS: 14171-67-6

Formula: C₁₉H₂₃ClN₂O

Color and Shape: Solid

Molecular weight: 330.8517

Ref: IN-DA001GXK

Clomipramine N-Oxide

CAS: 14171-67-6

Color and Shape: Neat

Ref: 86-MM0545.09

Clomipramine N-Oxide

CAS: 14171-67-6

Formula: C₁₉H₂₃ClN₂O

Molecular weight: 330.86

Ref: 4Z-C-195015

Clomipramine N-oxide

CAS: 14171-67-6

Clomipramine N-oxide is an active metabolite of clomipramine, which is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine. The drug is used to treat depression and obsessive-compulsive disorder. Clomipramine N-oxide is obtained by the reaction of clomipramine with nitrous acid in the presence of acetic acid. It has been found to have similar pharmacological properties as clomipramine, but also has an added depressant effect. Clomipramine N-oxide can be detected by liquid chromatography with a detection limit of 0.2 ng/mL and a linear range from 0.2 ng/mL to 2 μg/mL.

Formula: C₁₉H₂₃ClN₂O

Purity: Min. 95%

Molecular weight: 330.85 g/mol

Ref: 3D-FC20506

Clomipramine N-Oxide

Controlled Product

CAS: 14171-67-6

Stability Hygroscopic
Applications A metabolite of Clomipramine.
References Gottschalk, L., et al.: J. Pharm. Sci., 67, 155 (1978), de Jongh, G., et al.: Drug Metab. Dispos., 9, 48 (1981), Delbressine, L., et al.: Xenobiotica, 22, 227 (1992), Jaworski, T., et al.: J. Pharm. Sci., 82, 330 (1993), Kelder, J., et al.: J. Pharm. Pharmacol., 49, 403 (1997),

Formula: C₁₉H₂₃ClN₂O

Color and Shape: Neat

Molecular weight: 330.85

Ref: TR-C587060

Clomipramine N-Oxide

CAS: 14171-67-6

Formula: C₁₉H₂₃ClN₂O

Molecular weight: 330.85

Ref: ST-EA-CP-C30011