CAS 141725-88-4

Cetefloxacin

Description:

Cetefloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used in veterinary medicine for the treatment of bacterial infections in animals. The compound exhibits a mechanism of action that involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Cetefloxacin is known for its effectiveness against a variety of Gram-positive and Gram-negative bacteria, making it a valuable option in managing infections. The substance is typically administered orally or via injection, depending on the specific formulation and intended use. Its pharmacokinetic properties include good absorption and distribution in tissues, although it may be subject to resistance development in certain bacterial strains. Safety profiles indicate potential side effects, which can include gastrointestinal disturbances and, in rare cases, effects on cartilage development in young animals. As with all antibiotics, responsible use is essential to mitigate the risk of resistance and ensure continued efficacy in treating infections.

Formula: C₂₀H₁₆F₃N₃O₃

InChI: InChI=1/C20H16F3N3O3/c1-9-15(24)8-25(9)18-6-17-11(5-14(18)23)19(27)12(20(28)29)7-26(17)16-3-2-10(21)4-13(16)22/h2-7,9,15H,8,24H2,1H3,(H,28,29)/t9-,15+/m0/s1

Synonyms:

• Cetefloxacin [INN]
• E 4868
• (-)-7-((2S,3R)-3-Amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• Unii-Cfy01Mzd5T
• 3-Quinolinecarboxylic acid, 7-(3-amino-2-methyl-1-azetidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, (2S-trans)-
• 7-[(2S,3R)-3-amino-2-methylazetidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-[(2S,3R)-3-Amino-2-methyl-azetidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-quinoline-3-carboxylic acid

CAS: 141725-88-4

7-[(2S,3R)-3-Amino-2-methyl-azetidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-quinoline-3-carboxylic acid (ABT) is a drug that binds to bacterial enzymes and inhibits their ability to synthesize proteins. ABT is a conjugate of fluoroquinolone and an amino acid. As the drug is degradable by hydrolysis, it has been shown to be less toxic in Sprague Dawley rats than other fluoroquinolones. This drug has been used in diagnostic tests as a ligand for affinity ligands, but has not been approved for human use. The drug also possesses functional groups that are important for binding to reconstituted enzymes.br>br>ABT's ester linkages are degradable by hydrolysis and can be

Formula: C₂₀H₁₆F₃N₃O₃

Purity: Min. 95%

Molecular weight: 403.35 g/mol

Ref: 3D-FA30404

Cetefloxacin

CAS: 141725-88-4

Cetefloxacin (E 4868) is a broad-spectrum antibacterial antibiotic with a minimum inhibitory concentration (MIC) ranging from 0.007 to 8 µg/ml. In mice, cetefloxacin demonstrates favorable pharmacokinetic properties and provides protection against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

Formula: C₂₀H₁₆F₃N₃O₃

Molecular weight: 403.35

Ref: TM-T208886