CAS 141732-76-5

Exenatide acetate

Description:

Exenatide acetate is a synthetic peptide that mimics the action of the incretin hormone GLP-1 (glucagon-like peptide-1), which plays a crucial role in glucose metabolism. It is primarily used in the treatment of type 2 diabetes to improve glycemic control. The substance is characterized by its ability to stimulate insulin secretion in response to elevated blood glucose levels, inhibit glucagon release, and slow gastric emptying, thereby reducing postprandial blood sugar spikes. Exenatide acetate is administered via subcutaneous injection and has a prolonged half-life due to its acetate formulation, which enhances its stability and bioavailability. The peptide structure consists of 39 amino acids, and its pharmacological effects are mediated through the GLP-1 receptor. Common side effects may include gastrointestinal disturbances, such as nausea and vomiting, as well as potential risks of pancreatitis. Overall, Exenatide acetate represents a significant advancement in diabetes management, offering a mechanism that aligns with the body's natural regulatory processes for glucose homeostasis.

Formula: C₁₈₄H₂₈₂N₅₀O₆₀S·C₂H₄O₂

Synonyms:

• His-Gly-Gly-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH{2}
• ExenatideAcetate
• Exenatide
• EXENATIDE ACETATE
• ENFUVIRTIDE ACETATE
• EXENATIDE ACETATE(EXENDIN-4)

Exenatide Acetate

CAS: 141732-76-5

Formula: C₁₈₆H₂₈₆N₅₀O₆₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 4246.6238

Ref: IN-DA0039T6

Exenatide Acetate

CAS: 141732-76-5

Exenatide Acetate

Molecular weight: 4187g/mol

Ref: 54-BI9894

Exenatide Acetate

CAS: 141732-76-5

Formula: C₁₈₆H₂₈₆N₅₀O₆₂S

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 4262.67

Ref: BP-BPPG028

Exenatide

CAS: 141732-76-5

Exenatide (Extendin-4) is a glucagon-like protein-1 (GLP-1) receptor agonist.

Formula: C₁₈₆H₂₈₆N₅₀O₆₂S

Purity: 99.42%

Color and Shape: Solid

Molecular weight: 4247

Ref: TM-T8355

Exenatide-d5

CAS: 141732-76-5

Formula: C₁₈₆H₂₈₁D₅N₅₀O₆₂S

Molecular weight: 4251.71

Ref: 4Z-PE-141002

Exenatide Acetate

CAS: 141732-76-5

Formula: C₁₈₆H₂₈₆N₅₀O₆₂S

Molecular weight: 4246.62

Ref: 4Z-PE-141003

Exenatide-d5 Acetate

Controlled Product

CAS: 141732-76-5

Applications Exenatide-d5 Acetate is labelled Exenatide Acetate (E957300) which causes an increase in acinar cAMP without stimulating amylase release. Exenatide has found use as a medication of diabetes II.
References Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010); Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010); Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008); Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011);

Formula: C₁₈₆H₂₈₁D₅N₅₀O₆₂S

Color and Shape: Neat

Molecular weight: 4251.65

Ref: TR-E957302

Exenatide Acetate

Controlled Product

CAS: 141732-76-5

Applications A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.
References Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010); Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010); Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008); Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011);

Formula: C₁₈₆H₂₈₆N₅₀O₆₂S

Color and Shape: Neat

Molecular weight: 4246.62

Ref: TR-E957300

Exenatide acetate

CAS: 141732-76-5

Agonist of glucagon-like peptide GLP1 which is used for treatment of type 2 diabetes mellitus. Exenatide is more resistant to degradation by dipeptidyl peptidase IV than GLP1 and possesses GLP1-like glucoregulatory activities such as stimulation of insulin production by pancreatic β cells and lowering of serum glucagon levels during hyperglycaemia. In a mouse model for type 2 diabetes, exenatide was shown to reverse neuropathy and to possess anxiolytic and anti-depressant-like effects.

Formula: C₁₈₄H₂₈₂N₅₀O₆₀S·C₂H₄O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 4246.63

Ref: 3D-FE23212

Exenatide Acetate (1 to 12)

CAS: 141732-76-5

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₅₄H₈₃N₁₅O₂₁

Molecular weight: 1,278.4 g/mol

Ref: 3D-PP50812

Exenatide Acetate

CAS: 141732-76-5

Formula: C₁₈₄H₂₈₂N₅₀O₆₀SC₂H₄O₂

Molecular weight: 4186.63 : 60.05

Ref: ST-EA-CP-E77001