CAS 141801-26-5

Endomorphin-2

Description:

Endomorphin-2 is a naturally occurring peptide that belongs to the class of endogenous opioids, specifically derived from the proenkephalin precursor. It is composed of a sequence of amino acids, typically characterized by its high affinity for mu-opioid receptors, which play a crucial role in pain modulation, reward, and addictive behaviors. Endomorphin-2 is known for its analgesic properties, often exhibiting a stronger effect than morphine while having a lower potential for addiction. The substance is primarily found in the central nervous system and has been studied for its implications in pain relief and the treatment of various neurological disorders. Its structure includes a specific arrangement of amino acids that contributes to its biological activity and receptor binding capabilities. Additionally, research into endomorphin-2 has highlighted its potential therapeutic applications, although further studies are necessary to fully understand its mechanisms and effects in clinical settings.

Formula: C₃₂H₃₇N₅O₅

InChI: InChI=1/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1

SMILES: c1ccc(cc1)C[C@@H](C(=N)O)N=C([C@H](Cc1ccccc1)N=C([C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)O)N)O)O

Synonyms:

• Endomorphin-2 (Human, Bovine)
• Ypff-Nh2
• Tyr-Pro-Phe-Phe-Nh2
• (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-phenyl-ethyl]pyrrolidine-2-carboxamide
• L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide

L-PHENYLALANINAMIDE, L-TYROSYL-L-PROLYL-L-PHENYLALANYL-

CAS: 141801-26-5

Formula: C₃₂H₃₇N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 571.6667

Ref: IN-DA001H7A

Endomorphin 2

CAS: 141801-26-5

Formula: C₃₂H₃₇N₅O₅

Molecular weight: 571.67

Ref: 7W-GK8142

Endomorphin 2

CAS: 141801-26-5

Endomorphin 2

Purity: ≥95%

Molecular weight: 571.67g/mol

Ref: 54-BUP01971

Endomorphin 2

CAS: 141801-26-5

EM-2 reduces sEPSC frequency/amplitude in lamina IX motoneurons; CTOP reverses this. EM-2-IR affects limb muscles via presynaptic/postsynaptic mechanisms.

Formula: C₃₂H₃₇N₅O₅

Purity: 99.64%

Color and Shape: Solid

Molecular weight: 571.67

Ref: TM-T7218

Endomorphin 2

CAS: 141801-26-5

Formula: C₃₂H₃₇N₅O₅

Purity: 98%

Molecular weight: 571.678

Ref: 10-F300020

Endomorphin-2 trifluoroacetate salt

CAS: 141801-26-5

Endomorphin-2 is a cyclic peptide that is the endogenous ligand for the neurokinin-1 receptor and kappa-opioid receptors. It has been shown to have analgesic, anti-inflammatory, and antidiarrheal properties. Endomorphin-2 also has been shown to inhibit platelet aggregation and vasoconstriction in vivo. The biological activities of endomorphin-2 are similar to those of endomorphin-1, but it differs structurally in that it contains a single intramolecular hydrogen bond between the amide nitrogen of Tyr and Pro. This intramolecular hydrogen bond may be responsible for the high potency of endomorphin-2, as well as its conformational stability.

Formula: C₃₂H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 571.67 g/mol

Ref: 3D-FE109150