NMS-873, with the CAS number 1418013-75-8, is a small molecule that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of the protein MDM2 (Mouse Double Minute 2 homolog). MDM2 is known for its function in regulating the p53 tumor suppressor pathway, making NMS-873 a compound of interest in cancer research. The substance is characterized by its ability to disrupt the interaction between MDM2 and p53, thereby promoting the stabilization and activation of p53, which can lead to increased apoptosis in cancer cells. NMS-873 has been studied for its potential therapeutic applications in various malignancies, particularly those with dysfunctional p53 pathways. Its chemical structure and properties facilitate its role as a potent inhibitor, and ongoing research aims to further elucidate its efficacy and safety profile in clinical settings. As with many investigational compounds, detailed pharmacokinetic and pharmacodynamic studies are essential to fully understand its behavior in biological systems.

NMS-873

1418013-75-8: NMS-873, with the CAS number 1418013-75-8, is a small molecule that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of the protein MDM2 (Mouse Double Minute 2 homolog). MDM2 is known for its function in regulating the p53 tumor suppressor pathway, making NMS-873 a compound of interest in cancer research. The substance is characterized by its ability to disrupt the interaction between MDM2 and p53, thereby promoting the stabilization and activation of p53, which can lead to increased apoptosis in cancer cells. NMS-873 has been studied for its potential therapeutic applications in various malignancies, particularly those with dysfunctional p53 pathways. Its chemical structure and properties facilitate its role as a potent inhibitor, and ongoing research aims to further elucidate its efficacy and safety profile in clinical settings. As with many investigational compounds, detailed pharmacokinetic and pharmacodynamic studies are essential to fully understand its behavior in biological systems.

NMS 873

<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>

CAS 1418013-75-8

NMS-873

NMS 873

Ref: IN-DA009CDU

NMS-873

Ref: 54-BUP09702

NMS-873

Ref: TM-T1853