CAS 1419609-94-1

GSK2798745

CAS: 1419609-94-1

GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).

Formula: C₂₅H₂₈N₆O₃

Color and Shape: Solid

Molecular weight: 460.53

Ref: TM-T15434

GSK2798745

CAS: 1419609-94-1

GSK2798745 is a non-selective cation channel activator. It selectively activates the nicotinic acetylcholine receptor and has been shown to inhibit choroidal neovascularization in patients with age-related macular degeneration. GSK2798745 also inhibits pancreatic enzyme secretion, chronic cough, and cancer cell proliferation. The median plasma concentration of GSK2798745 is reached within 2 hours after administration and the half-life is about 4 hours. GSK2798745 does not cross the blood–brain barrier, which may explain its lack of central nervous system side effects.

Formula: C₂₅H₂₈N₆O₃

Purity: Min. 95%

Molecular weight: 460.5 g/mol

Ref: 3D-UGC60994