CAS 1419949-20-4

TNKS656

Description:

TNKS656, with the CAS number 1419949-20-4, is a small molecule inhibitor that specifically targets tankyrase enzymes, which are part of the poly(ADP-ribose) polymerase (PARP) family. This compound is primarily investigated for its potential therapeutic applications in cancer treatment, particularly in tumors with mutations in the Wnt signaling pathway. TNKS656 exhibits characteristics such as high selectivity for tankyrase 1 and tankyrase 2, leading to the disruption of the Wnt/β-catenin signaling pathway, which is often dysregulated in various cancers. The inhibition of tankyrases by TNKS656 results in the destabilization of β-catenin, promoting its degradation and thereby reducing the proliferation of cancer cells. Additionally, TNKS656 has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are crucial for its efficacy and safety profile in clinical settings. Overall, TNKS656 represents a promising avenue for targeted cancer therapy, particularly in tumors with specific genetic backgrounds.

Formula: C₂₇H₃₄N₄O₅

Synonyms:

• CS-1333
• 1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-
• NVP-TNKS656
• NVP-TNKS656 - TNKS 656
• TNKS656
• N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide
• N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide
• TNKS656; TNKS-656;TNKS 656

1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-

CAS: 1419949-20-4

Formula: C₂₇H₃₄N₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 494.5827

Ref: IN-DA001HI7

NVP-TNKS656

CAS: 1419949-20-4

NVP-TNKS656

Purity: ≥95%

Molecular weight: 494.58g/mol

Ref: 54-BUP03664

NVP-TNKS656

CAS: 1419949-20-4

NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.

Formula: C₂₇H₃₄N₄O₅

Purity: 99.59%

Color and Shape: Solid

Molecular weight: 494.58

Ref: TM-T3261

NVP-TNKS656

CAS: 1419949-20-4

NVP-TNKS656 is a small molecule that inhibits β-catenin in the microenvironment of colorectal cancer. β-catenin is an enzyme that helps regulate the Wnt pathway, which plays a role in tumor progression. NVP-TNKS656 binds to the tyrosine kinase domain of β-catenin and inhibits its activity by blocking the binding site for ATP. It also binds to other proteins involved in Wnt signaling, such as ARMET and GSK3β. This inhibition disrupts the normal function of these enzymes and prevents them from phosphorylating downstream targets, resulting in reduced cell proliferation and migration. NVP-TNKS656 has been shown to inhibit mouse tumors in vivo and reduces bone cancer incidence in mice with a genetic predisposition for this type of cancer.

Formula: C₂₇H₃₄N₄O₅

Purity: Min. 95%

Molecular weight: 494.58 g/mol

Ref: 3D-UGC94920