CAS 142001-63-6

Saredutant

Description:

Saredutant, with the CAS number 142001-63-6, is a chemical compound that has been investigated primarily for its potential therapeutic applications, particularly in the treatment of psychiatric disorders such as depression and anxiety. It functions as a selective antagonist of the neurokinin-1 (NK1) receptor, which is involved in the modulation of mood and stress responses. By blocking this receptor, Saredutant may help alleviate symptoms associated with these conditions. The compound is characterized by its specific binding affinity to the NK1 receptor, which distinguishes it from other substances that may interact with different neurochemical pathways. Additionally, Saredutant has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are crucial for determining its efficacy and safety profile in clinical settings. Ongoing research continues to explore its full potential and mechanisms of action, contributing to the understanding of neurokinin signaling in mental health.

Formula: C₃₁H₃₅Cl₂N₃O₂

InChI: InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1

InChI key: InChIKey=PGKXDIMONUAMFR-AREMUKBSSA-N

SMILES: N(C(C)=O)C1(CCN(CC[C@H](CN(C(=O)C2=CC=CC=C2)C)C3=CC(Cl)=C(Cl)C=C3)CC1)C4=CC=CC=C4

Synonyms:

• Benzamide, N-[(2S)-4-[4-(acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methyl-
• Benzamide, N-[4-[4-(acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methyl-, (S)-
• N-[(2S)-4-[4-(Acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
• N-[(2S)-4-[4-(acetylamino)-4-phenylpiperidin-1-yl]-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
• Sr 48968
• Sr 48968C
• Saredutant

Saredutant

CAS: 142001-63-6

Formula: C₃₁H₃₅Cl₂N₃O₂

Purity: 98.02%

Molecular weight: 552.5345

Ref: IN-DA009HW5

Actriol

CAS: 142001-63-6

Actriol

Purity: ≥95%

Molecular weight: 288.38g/mol

Ref: 54-BUP20791

Saredutant

CAS: 142001-63-6

Formula: C₃₁H₃₅Cl₂N₃O₂

Molecular weight: 552.55

Ref: 4Z-S-071001

Saredutant

CAS: 142001-63-6

Saredutant is a potent, selective, and orally bioavailable antagonist of the glucocorticoid receptor. This drug has been approved for the treatment of IBD (inflammatory bowel disease) in Japan. Saredutant has also been shown to be effective for treating cancer and bowel disorders that are induced by inflammation. Saredutant is a potent anti-inflammatory agent that inhibits neutrophil infiltration into the inflamed bowel mucosa and reduces mucosal edema. It also inhibits CD4+ T cells from producing proinflammatory cytokines such as IL-2, IFN-γ, and TNF-α. Saredutant has been shown to reduce systolic blood pressure in animal studies, suggesting that it may have antihypertensive effects.

Formula: C₃₁H₃₅Cl₂N₃O₂

Purity: Min. 95%

Molecular weight: 552.5 g/mol

Ref: 3D-SFA00163

Saredutant

CAS: 142001-63-6

Saredutant (SR 48968) is a selective neurokinin-2 (NK2) receptor antagonist that inhibits neurokinin A by blocking NK2 receptor, antidepressant and anxiolytic.

Formula: C₃₁H₃₅Cl₂N₃O₂

Purity: 99.12%

Color and Shape: Solid

Molecular weight: 552.54

Ref: TM-T16842