CAS 1420477-60-6: 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide

Description: The chemical substance known as 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide, with the CAS number 1420477-60-6, is a complex organic compound characterized by its multi-ring structure and the presence of various functional groups. It features an imidazo[1,5-a]pyrazine core, which is fused with an amino group and a benzamide moiety, contributing to its potential biological activity. The compound also contains a pyridinyl group and a pyrrolidine derivative, indicating possible interactions with biological targets. Its structural complexity suggests that it may exhibit unique pharmacological properties, potentially making it a candidate for drug development. The presence of a butynyl substituent may influence its lipophilicity and membrane permeability. Overall, this compound's intricate architecture and functional diversity position it as a subject of interest in medicinal chemistry and pharmacology, warranting further investigation into its therapeutic potential and mechanisms of action.

Formula: C₂₆H₂₃N₇O₂

InChI: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1

InChI key: InChIKey=WDENQIQQYWYTPO-IBGZPJMESA-N

SMILES: O=C(C#CC)N1CCCC1C2=NC(C=3C=CC(=CC3)C(=O)NC4=NC=CC=C4)=C5C(=NC=CN25)N

Synonyms:

• (S)-4-[8-Amino-3-[1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(pyridin-2-yl)benzamide
• 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide
• Acalabrutinib；ACP-196
• Acp 196
• Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-
• Calquence
• Acalabrutinib

Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-

CAS: 1420477-60-6

• Formula: C₂₆H₂₃N₇O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 465.5065

Acalabrutinib

CAS: 1420477-60-6

• Formula: C₂₆H₂₃N₇O₂
• Color and Shape: Pale Yellow Solid
• Molecular weight: 465.52

Acalabrutinib

CAS: 1420477-60-6

• Purity: 99.95%
• Molecular weight: 465.51g/mol

Acalabrutinib-d4

CAS: 1420477-60-6

• Formula: C₂₆H₁₉D₄N₇O₂
• Color and Shape: Yellow Solid
• Molecular weight: 469.54

Acalabrutinib

CAS: 1420477-60-6

Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase …

• Formula: C₂₆H₂₃N₇O₂
• Purity: 99.02% - 99.46%
• Color and Shape: Solid
• Molecular weight: 465.51

Acalabrutinib

CAS: 1420477-60-6

Applications Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. …

• Formula: C₂₆H₂₃N₇O₂
• Color and Shape: Neat
• Molecular weight: 465.51

Acalabrutinib

CAS: 1420477-60-6

Inhibitor of the Bruton tyrosine kinase

• Formula: C₂₆H₂₃N₇O₂
• Purity: Min. 98 Area-%
• Color and Shape: Solid
• Molecular weight: 465.51 g/mol

Acalabrutinib-d3

CAS: 1420477-60-6

• Formula: C₂₆D₃H₂₀N₇O₂
• Color and Shape: Neat
• Molecular weight: 468.525

Acalabrutinib Acetaldehyde

CAS: 1420477-60-6

• Formula: C₂₆H₂₅N₇O₃
• Color and Shape: Neat
• Molecular weight: 483.52