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CAS 1420477-60-6
:4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide
Description:
The chemical substance known as 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide, with the CAS number 1420477-60-6, is a complex organic compound characterized by its multi-ring structure and the presence of various functional groups. It features an imidazo[1,5-a]pyrazine core, which is fused with an amino group and a benzamide moiety, contributing to its potential biological activity. The compound also contains a pyridinyl group and a pyrrolidine derivative, indicating possible interactions with biological targets. Its structural complexity suggests that it may exhibit unique pharmacological properties, potentially making it a candidate for drug development. The presence of a butynyl substituent may influence its lipophilicity and membrane permeability. Overall, this compound's intricate architecture and functional diversity position it as a subject of interest in medicinal chemistry and pharmacology, warranting further investigation into its therapeutic potential and mechanisms of action.
Formula:C26H23N7O2
InChI:InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
InChI key:InChIKey=WDENQIQQYWYTPO-IBGZPJMESA-N
SMILES:C(C#CC)(=O)N1[C@H](C=2N3C(=C(N2)C4=CC=C(C(NC5=CC=CC=N5)=O)C=C4)C(N)=NC=C3)CCC1
Synonyms:- (S)-4-[8-Amino-3-[1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(pyridin-2-yl)benzamide
- 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide
- Acalabrutinib；ACP-196
- Acp 196
- Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-
- Calquence
- Acalabrutinib
- ACP196,Acalabrutinib
- 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
- ACP196
- α-Aminoisobutanoic acid
- ACP-196; ACP196; ACP 196
- α-Dimethylglycine
- CS-1558
- BTK Inhibitor Pharma Raw Powder Acalabrutinib / ACP-196 For Treatment of Cancer
- EOS-60753
- ACP196 1420477-60-6
- See more synonyms
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Found 9 products.
Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-
CAS:Formula:C26H23N7O2Purity:98%Color and Shape:SolidMolecular weight:465.5065Acalabrutinib
CAS:Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.Formula:C26H23N7O2Purity:98.94% - 99.64%Color and Shape:SolidMolecular weight:465.51Acalabrutinib
CAS:Controlled Product<p>Applications Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).<br>References Byrd; et al. (2015). "Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia."; "AstraZeneca to buy Acerta for blood cancer drug". www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.<br></p>Formula:C26H23N7O2Color and Shape:NeatMolecular weight:465.51Acalabrutinib
CAS:<p>Inhibitor of the Bruton tyrosine kinase</p>Formula:C26H23N7O2Purity:Min. 98 Area-%Color and Shape:SolidMolecular weight:465.51 g/molAcalabrutinib-d3
CAS:Controlled ProductFormula:C26D3H20N7O2Color and Shape:NeatMolecular weight:468.525Acalabrutinib Acetaldehyde
CAS:Controlled ProductFormula:C26H25N7O3Color and Shape:NeatMolecular weight:483.52
![Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA001HMC.jpg&w=3840&q=75)
