CAS 1421-69-8

N-[(Phenylmethoxy)carbonyl]glycyl-L-leucine

Description:

N-[(Phenylmethoxy)carbonyl]glycyl-L-leucine, with the CAS number 1421-69-8, is a synthetic compound that belongs to the class of peptides. It features a glycine residue linked to an L-leucine amino acid, with a phenylmethoxycarbonyl (PMOC) protecting group. This structure imparts specific characteristics, including its potential use in peptide synthesis and as a building block in medicinal chemistry. The PMOC group enhances the compound's stability and solubility, making it suitable for various biochemical applications. The presence of the phenyl group contributes to its hydrophobic properties, which can influence its interaction with biological membranes and proteins. Additionally, the compound may exhibit specific biological activities, depending on its conformation and the presence of functional groups. Its synthesis typically involves standard peptide coupling techniques, and it may be analyzed using methods such as high-performance liquid chromatography (HPLC) or mass spectrometry to confirm purity and identity. Overall, N-[(Phenylmethoxy)carbonyl]glycyl-L-leucine serves as an important intermediate in peptide chemistry and drug development.

Formula: C₁₆H₂₂N₂O₅

InChI: InChI=1S/C16H22N2O5/c1-11(2)8-13(15(20)21)18-14(19)9-17-16(22)23-10-12-6-4-3-5-7-12/h3-7,11,13H,8-10H2,1-2H3,(H,17,22)(H,18,19)(H,20,21)/t13-/m0/s1

InChI key: InChIKey=MRRLFGAIRAUOCS-ZDUSSCGKSA-N

SMILES: C(OC(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)C1=CC=CC=C1

Synonyms:

• <span class="text-smallcaps">L</span>-Leucine, N-[(phenylmethoxy)carbonyl]glycyl-
• <span class="text-smallcaps">L</span>-Leucine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-
• Leucine, N-(N-carboxyglycyl)-, N-benzyl ester
• Leucine, N-(N-carboxyglycyl)-, N-benzyl ester, <span class="text-smallcaps">L</span>-
• N-(Benzyloxycarbonyl)glycyl-<span class="text-smallcaps">L</span>-leucine
• N-(Benzyloxycarbonyl)glycylleucine
• N-Benzyloxycarbonylglycyl-L-leucine
• N-Carbobenzoxyglycyl-<span class="text-smallcaps">L</span>-leucine
• N-[(Phenylmethoxy)carbonyl]glycyl-<span class="text-smallcaps">L</span>-leucine
• N-[(benzyloxy)carbonyl]glycyl-D-leucine
• N-[(benzyloxy)carbonyl]glycylleucine
• NSC 89638
• Z-Gly-Leu-OH
• Leucine, N-(N-carboxyglycyl)-, N-benzyl ester, L-
• L-Leucine, N-[(phenylmethoxy)carbonyl]glycyl-
• L-Leucine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-

Z-Gly-Leu

CAS: 1421-69-8

Z-Gly-Leu is a monoclonal antibody that inhibits the enzyme protease. It binds to the active site of the enzyme and prevents it from cleaving peptides into smaller fragments. The antibody also binds to casein, a protein found in milk, and soybean trypsin inhibitor. This prevents these enzymes from degrading other proteins in the body. The antibody is reactive at phase transition temperatures and has been shown to be effective on wild-type mice.

Formula: C₁₆H₂₂N₂O₅

Purity: Min. 95%

Molecular weight: 322.36 g/mol

Ref: 3D-SGL-3019

Z-Gly-Leu-OH

CAS: 1421-69-8

Z-Gly-Leu-OH is a synthetic peptide that is used as a substrate for proteases. It contains the amino acid sequence Gly-Leu-OH and has been shown to inhibit serine proteases with irreversible inhibition. Z-Gly-Leu-OH inhibits protease activity by binding to the enzyme's active site, which prevents it from catalyzing reactions and stabilizing the product of the reaction. The substrate can be cleaved by a protease in two ways: (1) hydrolysis of the amide bond between Gly and Leu or (2) protonation of the amide bond between Gly and Leu followed by elimination of water. These reactions are reversible because they are dependent on pH. In order to measure enzyme activity using this substrate, it must be conjugated with a fluorescent dye so that fluorescence can be detected following cleavage.

Formula: C₁₆H₂₂N₂O₅

Purity: Min. 95%

Molecular weight: 322.36 g/mol

Ref: 3D-FG111476