CAS 142128-59-4

(+)-Ketoconazole

Description:

(+)-Ketoconazole is an antifungal medication belonging to the imidazole class, primarily used to treat fungal infections and certain skin conditions. It exhibits a broad spectrum of activity against various fungi, including dermatophytes and yeasts. The substance is characterized by its ability to inhibit the synthesis of ergosterol, a crucial component of fungal cell membranes, thereby disrupting their integrity and function. Chemically, it is a chiral compound, with the (+) designation indicating its specific optical activity. Ketoconazole is typically administered orally or topically, and its solubility in organic solvents is notable, while its solubility in water is limited. The compound has a relatively complex structure, featuring multiple rings and functional groups that contribute to its pharmacological properties. Additionally, it is important to monitor for potential side effects, including hepatotoxicity and interactions with other medications, due to its influence on liver enzymes. Overall, (+)-Ketoconazole is a significant agent in antifungal therapy, with specific characteristics that enhance its efficacy against fungal pathogens.

Formula: C₂₆H₂₈Cl₂N₄O₄

InChI: InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1

InChI key: InChIKey=XMAYWYJOQHXEEK-OZXSUGGESA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5

Synonyms:

• (+)-Ketoconazole
• 1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone
• Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, (2R-cis)-
• Piperazine, 1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-
• Ethanone, 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-

Ethanone, 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-

CAS: 142128-59-4

Formula: C₂₆H₂₈Cl₂N₄O₄

Purity: 99.77%

Color and Shape: Solid

Molecular weight: 531.4309

Ref: IN-DA001HTF

(+)-Ketoconazole

CAS: 142128-59-4

(+)-Ketoconazole ((+)-R 41400) is a antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.

Formula: C₂₆H₂₈Cl₂N₄O₄

Purity: 99.79%

Color and Shape: Solid

Molecular weight: 531.43

Ref: TM-T13464

(+)-Ketoconazole

Controlled Product

CAS: 142128-59-4

Formula: C₂₆H₂₈Cl₂N₄O₄

Color and Shape: Neat

Molecular weight: 531.431

Ref: TR-K186020