CAS 1421372-66-8: AZD9291DA HCl salt

Description: AZD9291DA HCl salt, also known as Osimertinib, is a potent, selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, particularly effective against certain mutations associated with non-small cell lung cancer (NSCLC). This compound is characterized by its ability to irreversibly bind to the mutant forms of EGFR, thereby inhibiting tumor growth. As a hydrochloride salt, it enhances the solubility and stability of the active pharmaceutical ingredient, facilitating its formulation for oral administration. AZD9291DA exhibits a favorable pharmacokinetic profile, with good bioavailability and a half-life that supports once-daily dosing. Its mechanism of action involves blocking downstream signaling pathways that promote cell proliferation and survival, making it a critical therapeutic option for patients with EGFR mutation-positive NSCLC. Additionally, the compound has undergone extensive clinical trials, demonstrating efficacy and a manageable safety profile, which has led to its approval for clinical use in various jurisdictions.

Synonyms:

• Mutated EGFR-IN-1
• N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine

CAS: 1421372-66-8

• Formula: C₂₅H₃₁N₇O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 445.5599

Mutated EGFR-IN-1

CAS: 1421372-66-8

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, …

• Formula: C₂₅H₃₁N₇O
• Purity: 98.91%
• Color and Shape: Solid
• Molecular weight: 445.56

N1-(2-(Dimethylamino)Ethyl)-5-Methoxy-N1-Methyl-N4-(4-(1-Methyl-1H-Indol-3-Yl)Pyrimidin-2-Yl)Benzene-1,2,4-Triamine

CAS: 1421372-66-8

• Purity: 98%
• Molecular weight: 445.56g/mol

Mutated EGFR-IN-1

CAS: 1421372-66-8

• Purity: 99.72%
• Molecular weight: 445.56g/mol

Osimertinib Impurity 16

CAS: 1421372-66-8

• Formula: C₂₅H₃₁N₇O
• Molecular weight: 445.57

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine

CAS: 1421372-66-8

• Color and Shape: Neat

N1-2-(Dimethylamino) ethyl) - 5- methoxy- N1- methyl- N4- (4- (1- methyl- 1H- indol- 3- yl) pyrimidin- 2- yl) benzene- 1, 2, 4- tria mine

CAS: 1421372-66-8

Intermediate in the synthesis of osimertinib (AZD9291)

• Formula: C₂₅H₃₁N₇O
• Purity: Min. 95%
• Molecular weight: 445.56 g/mol