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CAS 1421372-66-8

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AZD9291DA HCl salt

Description:
AZD9291DA HCl salt, also known as Osimertinib, is a potent, selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, particularly effective against certain mutations associated with non-small cell lung cancer (NSCLC). This compound is characterized by its ability to irreversibly bind to the mutant forms of EGFR, thereby inhibiting tumor growth. As a hydrochloride salt, it enhances the solubility and stability of the active pharmaceutical ingredient, facilitating its formulation for oral administration. AZD9291DA exhibits a favorable pharmacokinetic profile, with good bioavailability and a half-life that supports once-daily dosing. Its mechanism of action involves blocking downstream signaling pathways that promote cell proliferation and survival, making it a critical therapeutic option for patients with EGFR mutation-positive NSCLC. Additionally, the compound has undergone extensive clinical trials, demonstrating efficacy and a manageable safety profile, which has led to its approval for clinical use in various jurisdictions.
Synonyms:
  • Mutated EGFR-IN-1
  • N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine
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