CAS 1421373-99-0

N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide

Description:

N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide, with CAS number 1421373-99-0, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amines, methoxy, and propenamide. This compound is likely to exhibit properties typical of small organic molecules, including moderate solubility in organic solvents and potential bioactivity due to its intricate arrangement of aromatic and heterocyclic rings. The presence of the indole and pyrimidine moieties suggests potential interactions with biological targets, making it of interest in medicinal chemistry. Its molecular weight, polarity, and specific reactivity would depend on the arrangement of its substituents, influencing its pharmacokinetic and pharmacodynamic profiles. As with many compounds of this nature, safety and handling precautions are essential, and its stability under various conditions should be evaluated for practical applications.

Formula: C₂₇H₃₁N₇O₂

InChI: InChI=1S/C27H31N7O2/c1-6-26(35)30-21-15-22(25(36-5)16-24(21)33(3)14-13-28-2)32-27-29-12-11-20(31-27)19-17-34(4)23-10-8-7-9-18(19)23/h6-12,15-17,28H,1,13-14H2,2-5H3,(H,30,35)(H,29,31,32)

InChI key: InChIKey=ZROCWKZRGJYPTG-UHFFFAOYSA-N

SMILES: CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCNC)C)C(NC(C=C)=O)=C4)=NC=C3

Synonyms:

• N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide
• 2-Propenamide, N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-
• AZ 7550

AZ7550

CAS: 1421373-99-0

Formula: C₂₇H₃₁N₇O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 485.5807

Ref: IN-DA01EO7O

AZ7550

CAS: 1421373-99-0

AZ7550

Purity: ≥95%

Molecular weight: 485.58g/mol

Ref: 54-BUP01438

Osimertinib Impurity 2 DiHCl

CAS: 1421373-99-0

Formula: C₂₇H₃₁N₇O₂·2HCl

Color and Shape: Yellow Solid

Molecular weight: 485.59 2*36.46

Ref: 4Z-A-194015

AZ7550

CAS: 1421373-99-0

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

Formula: C₂₇H₃₁N₇O₂

Purity: 97.07% - 99.75%

Color and Shape: Solid

Molecular weight: 485.58

Ref: TM-T13564

AZ7550

CAS: 1421373-99-0

Applications AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).
References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);

Formula: C₂₇H₃₁N₇O₂

Color and Shape: Neat

Molecular weight: 485.581

Ref: TR-A965495

N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide

CAS: 1421373-99-0

N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide is a selective kinase inhibitor, which is synthesized through advanced chemical processes targeting specific molecular structures. This compound operates by selectively inhibiting certain protein kinases involved in cellular signaling pathways, effectively disrupting proliferative signaling in cancer cells.

Formula: C₂₇H₃₁N₇O₂

Purity: Min. 95%

Molecular weight: 485.6 g/mol

Ref: 3D-WGC37399

Osimertinib N Desmethyl Impurity

CAS: 1421373-99-0

Formula: C₂₇H₃₁N₇O₂

Molecular weight: 485.59

Ref: ST-EA-CP-O17018