LasR antagonist 1, identified by its CAS number 1421464-74-5, is a chemical compound that functions as an antagonist of the LasR receptor, which is part of the quorum sensing system in Pseudomonas aeruginosa. This compound is significant in the field of microbiology and pharmacology due to its potential role in disrupting bacterial communication and biofilm formation, which are critical for the pathogenicity of this opportunistic pathogen. LasR antagonists like this compound are of interest for developing new therapeutic strategies to combat antibiotic resistance and treat infections caused by Pseudomonas aeruginosa. The characteristics of LasR antagonist 1 include its molecular structure, which typically features specific functional groups that enable it to bind to the LasR receptor and inhibit its activity. Additionally, the compound's solubility, stability, and bioavailability are important factors that influence its efficacy as a therapeutic agent. Research into LasR antagonists continues to explore their potential applications in clinical settings, particularly in treating chronic infections associated with cystic fibrosis and other conditions.

LasR antagonist 1

1421464-74-5: LasR antagonist 1, identified by its CAS number 1421464-74-5, is a chemical compound that functions as an antagonist of the LasR receptor, which is part of the quorum sensing system in Pseudomonas aeruginosa. This compound is significant in the field of microbiology and pharmacology due to its potential role in disrupting bacterial communication and biofilm formation, which are critical for the pathogenicity of this opportunistic pathogen. LasR antagonists like this compound are of interest for developing new therapeutic strategies to combat antibiotic resistance and treat infections caused by Pseudomonas aeruginosa. The characteristics of LasR antagonist 1 include its molecular structure, which typically features specific functional groups that enable it to bind to the LasR receptor and inhibit its activity. Additionally, the compound's solubility, stability, and bioavailability are important factors that influence its efficacy as a therapeutic agent. Research into LasR antagonists continues to explore their potential applications in clinical settings, particularly in treating chronic infections associated with cystic fibrosis and other conditions.

<p>LasR antagonist 1 (Compound 7), with an IC50 of 0.4 μM, is an effective antagonist of LasR that modulates quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa [1].</p>

CAS 1421464-74-5

LasR antagonist 1

LasR antagonist 1

Ref: TM-T86799