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CAS 142182-63-6

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delta(3)-Cefotiam

Description:
Delta(3)-Cefotiam is a broad-spectrum cephalosporin antibiotic, characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a variety of Gram-positive and Gram-negative bacteria. It is a semi-synthetic derivative of cefotiam, which enhances its stability against certain beta-lactamases, enzymes produced by bacteria that can inactivate many antibiotics. Delta(3)-Cefotiam is typically administered parenterally and is used in the treatment of various infections, including respiratory tract infections, urinary tract infections, and skin infections. Its pharmacokinetic profile includes good tissue penetration and a relatively short half-life, necessitating multiple doses for optimal therapeutic effect. The compound is generally well-tolerated, though potential side effects may include allergic reactions, gastrointestinal disturbances, and alterations in blood parameters. As with other antibiotics, the emergence of resistance is a concern, underscoring the importance of appropriate use in clinical settings. Overall, delta(3)-Cefotiam represents a valuable option in the antibiotic arsenal, particularly for infections caused by susceptible organisms.
Formula:C18H23N9O4S3
InChI:InChI=1/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h6,8,12-13,15H,3-5,7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)
SMILES:CN(C)CCn1c(nnn1)SCC1=CSC2C(C(=O)N2C1C(=O)O)N=C(Cc1csc(=N)[nH]1)O
Synonyms:
  • 7-(((2-Amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-3-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo(4.2.0)oct-3-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-
  • 7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid
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