CAS 1421923-86-5

KPT-330,(E)-RN

Description:

KPT-330, also known as (E)-RN, is a small molecule inhibitor primarily recognized for its role as a selective inhibitor of the nuclear export protein exportin 1 (XPO1). This compound has garnered attention in the field of cancer research due to its potential to enhance the efficacy of various anticancer therapies by promoting the accumulation of tumor suppressor proteins in the nucleus. KPT-330 exhibits a unique mechanism of action, disrupting the export of proteins that are crucial for tumor cell survival and proliferation. Its chemical structure features specific functional groups that contribute to its binding affinity and selectivity for XPO1. In preclinical studies, KPT-330 has shown promise in various cancer models, leading to ongoing investigations into its therapeutic potential and safety profile in clinical settings. As research continues, KPT-330 may provide insights into novel treatment strategies for cancers characterized by aberrant nuclear export processes.

2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2E)-

CAS: 1421923-86-5

Formula: C₁₇H₁₁F₆N₇O

Purity: 95%

Color and Shape: Solid

Molecular weight: 443.306

Ref: IN-DA001HXB

(E)-KPT330

CAS: 1421923-86-5

(E)-KPT330

Purity: ≥98%

Molecular weight: 443.31g/mol

Ref: 54-BUP09498

(E)-KPT330

CAS: 1421923-86-5

(E)-RN (KPT 330) is a CRM1-selective inhibitor of nuclear export. (E)-RN inhibits protein trafficking from the nucleus and induces cell cycle arrest.

Formula: C₁₇H₁₁F₆N₇O

Purity: 98.69% - 99.49%

Color and Shape: Solid

Molecular weight: 443.31

Ref: TM-T1844