CAS 1421936-85-7

Iclepertin

Description:

Iclepertin, with the CAS number 1421936-85-7, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential use in the treatment of type 2 diabetes. It functions as a DPP-4 (dipeptidyl peptidase-4) inhibitor, which plays a crucial role in glucose metabolism by prolonging the action of incretin hormones, thereby enhancing insulin secretion and reducing glucagon levels in response to meals. This mechanism helps to lower blood sugar levels in patients with type 2 diabetes. Iclepertin is characterized by its specific molecular structure, which contributes to its pharmacological activity and selectivity. The compound is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. As with many pharmaceutical agents, potential side effects and interactions with other medications are important considerations in its use. Overall, Iclepertin represents a promising therapeutic option in diabetes management, reflecting ongoing advancements in drug development for metabolic disorders.

Formula: C₂₀H₁₈F₆N₂O₅S

Synonyms:

• [5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[(1R,5R)-1-(5-trifluoromethyl-isoxazol-3-yl)-3-aza-bicyclo[3.1.0]
• Methanone, [5-(methylsulfonyl)-2-[(1R)-2,2,2-trifluoro-1-methylethoxy]phenyl][(1R,5R)-1-[5-(trifluoromethyl)-3-isoxazolyl]-3-azabicyclo[3.1.0]hex-3-yl]-
• [5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[(1R,5R)-1-(5-trifluoromethyl-isoxazol-3-yl)-3-aza-bicyclo
• Iclepertin
• Iclepertin (BI-425809)

[5-​(Methylsulfonyl)​-​2-​[(1R)​-​2,​2,​2-​trifluoro-​1-​methylethoxy]​phenyl]​[(1R,​5R)​-​1-​[5-​(trifluoromethyl)​-​3-​isoxazolyl]​-​3-​azabicyclo[3.1.0]​hex-​3-​yl]​-methanone

CAS: 1421936-85-7

Formula: C₂₀H₁₈F₆N₂O₅S

Purity: 99%

Molecular weight: 512.4227

Ref: IN-DA01WSTW

Iclepertin

CAS: 1421936-85-7

Iclepertin

Purity: ≥98%

Molecular weight: 512.42g/mol

Ref: 54-BUP02852

[5-​(Methylsulfonyl)​-​2-​[(1R)​-​2,​2,​2-​trifluoro-​1-​methylethoxy]​phenyl]​[(1R,​5R)​-​1-​[5-​(trifluoromethyl)​-​3-​isoxazolyl]​-​3-​azabicyclo[3.1.0]​hex-​3-​yl]​-methanone

Controlled Product

CAS: 1421936-85-7

Formula: C₂₀H₁₈F₆N₂O₅S

Color and Shape: Neat

Molecular weight: 512.423

Ref: TR-M416050

BI 425809

CAS: 1421936-85-7

BI 425809 is a drug that belongs to the class of selective serotonin reuptake inhibitors (SSRIs) and has been shown in clinical studies to be effective in the treatment of depression. The safety profile of BI 425809 has been established in clinical trials with healthy Chinese subjects, where it was found that the drug had no harmful effects at doses up to 400 mg/day. The concentration-time curve for BI 425809 showed an interactive response with food intake, which may indicate a need for dosage adjustment when taken with food. Pharmacokinetic properties have been evaluated in healthy Chinese subjects, showing that oral absorption is rapid and complete; elimination is mainly by hepatic metabolism; and elimination half-life is approximately 12 hours. BI 425809 has a low potential for abuse as it does not bind to dopamine receptors or produce any rewarding effects.

Purity: Min. 95%

Ref: 3D-FM180750

Iclepertin

CAS: 1421936-85-7

Iclepertin (BI-425809) is a GlyT1 inhibitor.Iclepertin is used for the treatment of Alzheimer;s disease and other CNS disorders.

Formula: C₂₀H₁₈F₆N₂O₅S

Purity: 98.89% - 98.93%

Color and Shape: Solid

Molecular weight: 512.42

Ref: TM-T37089