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CAS 142203-64-3

:

1-hydroxy-7,9-dideacetylbaccatin I

Description:
1-Hydroxy-7,9-dideacetylbaccatin I is a chemical compound derived from the natural product baccatin III, which is a precursor to the anticancer drug paclitaxel (Taxol). This compound features a hydroxyl group at the 1-position and lacks acetyl groups at the 7 and 9 positions, distinguishing it from its acetylated counterparts. It is characterized by its complex polycyclic structure, which includes a taxane core, contributing to its biological activity. The presence of the hydroxyl group enhances its solubility and potential reactivity, making it a subject of interest in medicinal chemistry. Its CAS number, 142203-64-3, allows for precise identification in chemical databases. While specific biological activities may vary, compounds related to baccatin III are often studied for their potential antitumor properties, as they can interfere with microtubule dynamics, a mechanism crucial for cell division. Overall, 1-hydroxy-7,9-dideacetylbaccatin I represents a significant compound in the exploration of taxane derivatives for therapeutic applications.
Formula:C28H40O12
InChI:InChI=1/C28H40O12/c1-12-17(37-13(2)29)10-28(35)24(40-16(5)32)22-26(8,18(33)9-19(38-14(3)30)27(22)11-36-27)23(34)21(39-15(4)31)20(12)25(28,6)7/h17-19,21-24,33-35H,9-11H2,1-8H3/t17-,18-,19-,21+,22-,23-,24-,26+,27+,28+/m0/s1
Synonyms:
  • 1-Hydroxy-7,9-dideacetyl baccatin I
  • Hddabi
  • (2Alpha,4Xi,5Alpha,7Beta,9Alpha,10Beta,13Alpha)-1,7,9-Trihydroxy-4,20-Epoxytax-11-Ene-2,5,10,13-Tetrayl Tetraacetate
  • (2Alpha,4Alpha,5Alpha,7Beta,9Alpha,10Beta,13Alpha)-1,7,9-Trihydroxy-4,20-Epoxytax-11-Ene-2,5,10,13-Tetrayl Tetraacetate
  • 1-Hydroxy-7,9-dideacetylbaccatin I
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