CAS 142217-77-4

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

Description:

The chemical substance with the name "(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol" and CAS number "142217-77-4" is a complex organic compound characterized by its multi-functional groups and stereochemistry. It features a cyclopentanol core, which is a five-membered cyclic alcohol, and is substituted with multiple benzyloxy groups, enhancing its lipophilicity and potential biological activity. The presence of an amino group and a purine derivative suggests that this compound may exhibit properties relevant to nucleic acid chemistry or serve as a potential pharmaceutical agent. The specific stereochemistry indicated by the (1S,2S,3S,5S) configuration implies that the compound has defined spatial arrangements, which can significantly influence its reactivity and interaction with biological targets. Overall, this compound's structural complexity and functional groups suggest potential applications in medicinal chemistry, particularly in the development of therapeutics targeting nucleic acid-related processes.

Formula: C₃₂H₃₃N₅O₄

InChI: InChI=1/C32H33N5O4/c33-32-35-30-28(31(36-32)41-19-24-14-8-3-9-15-24)34-21-37(30)26-16-27(40-18-23-12-6-2-7-13-23)25(29(26)38)20-39-17-22-10-4-1-5-11-22/h1-15,21,25-27,29,38H,16-20H2,(H2,33,35,36)/t25-,26+,27+,29+/m1/s1

Synonyms:

• (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cydopentanol
• Entecavir intermediate N4
• (1S,2S,3S,5S)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-((4-methylbenzyloxy)methyl)cyclopentanol
• Ent-4
• Intermediate of Entecavir 2
• (1S,2S,3S,5S)-5-(2-amino-6-(benzyloxyl)-9H-purin-9yl)-3-(benzyloxymethyl)cyclopentanol
• (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)  cyclopentanol

Cyclopentanol, 5-[2-amino-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, (1S,2S,3S,5S)-

CAS: 142217-77-4

Formula: C₃₂H₃₃N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 551.6355

Ref: IN-DA001HZM

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

CAS: 142217-77-4

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

Purity: 98%

Ref: 54-OR1037754

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

CAS: 142217-77-4

Purity: 97%

Molecular weight: 551.64697265625

Ref: 10-F692827

Entecavir Impurity 36

CAS: 142217-77-4

Formula: C₃₂H₃₃N₅O₄

Molecular weight: 551.65

Ref: 4Z-E-2357

(2R,3R,5R)-5-[2-Amino-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol

Controlled Product

CAS: 142217-77-4

Applications (2R,3R,5R)-5-[2-Amino-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol is an intermediate in the preparation of ent-Entecavir (E558905).

Formula: C₃₂H₃₃N₅O₄

Color and Shape: Neat

Molecular weight: 551.635

Ref: TR-A600160

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

CAS: 142217-77-4

(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol is a synthetic compound that is used to treat patients with chronic myeloid leukemia. It has been shown to inhibit tyrosine kinase and interacts with the guanine binding site of the purine nucleoside phosphorylase. This drug also inhibits the enzyme (deoxy)ribonucleotide reductase and competes with adenosine for binding to adenosine receptors. The stereoisomers of this drug are active against chronic myeloid leukemia cells. The S enantiomer is more potent than the R enantiomer and exhibits greater selectivity for leukemic cells than healthy cells. It has also been shown to inhibit nitric oxide synthase and may have anti-

Formula: C₃₂H₃₃N₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 551.64 g/mol

Ref: 3D-NA32025

Entecavir Impurity 18

CAS: 142217-77-4

Formula: C₃₂H₃₃N₅O₄

Molecular weight: 551.65

Ref: ST-EA-CP-E36023