CAS 142227-49-4

(R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL

Description:

(R)-(+)-4'-Hydroxyphenyl-carvedilol is a chiral compound that belongs to the class of beta-blockers, which are primarily used in the treatment of cardiovascular conditions. This substance is a derivative of carvedilol, known for its dual action as both a beta-adrenergic antagonist and an alpha-1 adrenergic antagonist. The (R)-enantiomer is particularly significant due to its enhanced pharmacological activity compared to its (S)-counterpart. The presence of the hydroxyl group on the phenyl ring contributes to its solubility and interaction with biological targets. This compound exhibits properties such as antioxidant activity, which may provide additional therapeutic benefits. Its stereochemistry plays a crucial role in its efficacy and safety profile, making it important for drug development and clinical applications. As with many beta-blockers, it may have side effects, including fatigue and dizziness, and its use should be monitored in patients with specific health conditions. Overall, (R)-(+)-4'-hydroxyphenyl-carvedilol represents a significant advancement in cardiovascular pharmacotherapy.

Formula: C₂₄H₂₆N₂O₅

Synonyms:

• (S)-(-)-4'-Hydroxyphenyl-Carvedilol
• (R)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
• (R)-4-Hydroxycarvedilol
• (R)-Bm 140686
• (R)-Bm 14686
• (S)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
• (S)-4-Hydroxycarvedilol
• Carvedilol 4-Hydroxy Metabolite
• (S)-BM 14686
• Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
• (R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL
• 4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]aMino]ethoxy]-3-Methoxyphenol

4'-hydroxyphenyl Carvedilol

CAS: 142227-49-4

Formula: C₂₄H₂₆N₂O₅

Color and Shape: Solid

Molecular weight: 422.4736

Ref: IN-DA001I05

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

CAS: 142227-49-4

4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol. Carvedilol is a beta-blocker/alpha-1 blocker.

Formula: C₂₄H₂₆N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 422.47

Ref: TM-T10686

4'-Hydroxyphenyl Carvedilol

CAS: 142227-49-4

Formula: C₂₄H₂₆N₂O₅

Color and Shape: Brown Solid

Molecular weight: 422.48

Ref: 4Z-C-024

4’-Hydroxyphenyl Carvedilol

Controlled Product

CAS: 142227-49-4

Applications A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.
References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),

Formula: C₂₄H₂₆N₂O₅

Color and Shape: Off White Solid

Molecular weight: 422.47

Ref: TR-H949120

4’-Hydroxyphenyl Carvedilol Hydrochloride

Controlled Product

CAS: 142227-49-4

Formula: C₂₄H₂₆N₂O₅·HCl

Color and Shape: Neat

Molecular weight: 458.935

Ref: TR-H949530

4'-Hydroxyphenyl carvedilol

CAS: 142227-49-4

4'-Hydroxyphenyl carvedilol is a metabolite of carvedilol, which is an inhibitor of the enzyme catechol-O-methyltransferase. 4'-hydroxyphenyl carvedilol has been found to be active against human serum and rat liver microsomes. It has been shown to have a matrix effect on metabolic rate and analytical method. The stereoselective metabolism of 4'-hydroxyphenyl carvedilol occurs in femoral vein and spectrometer samples. This compound also inhibits the activity of matrix enzymes such as diazepam and other enzyme inhibitors, thereby increasing the bioavailability of drugs that are substrates for these enzymes.

Formula: C₂₄H₂₆N₂O₅

Purity: Min. 95%

Molecular weight: 422.47 g/mol

Ref: 3D-FH24452

4-Hydroxy Carvedilol

CAS: 142227-49-4

Formula: C₂₄H₂₆N₂O₅

Molecular weight: 422.48

Ref: ST-EA-CP-C10034