CAS 142340-99-6: Adefovir dipivoxil
Description:Adefovir dipivoxil is an antiviral medication primarily used in the treatment of chronic hepatitis B virus (HBV) infection. It is a prodrug of adefovir, which means it is converted into its active form in the body. The compound is characterized by its ability to inhibit viral DNA polymerase, thereby preventing the replication of the virus. Adefovir dipivoxil is typically administered orally and is known for its relatively low toxicity profile compared to other antiviral agents. Its chemical structure includes a phosphonate group, which contributes to its mechanism of action. The substance is soluble in water and exhibits stability under physiological conditions. Common side effects may include nephrotoxicity and gastrointestinal disturbances, necessitating monitoring of renal function during treatment. Adefovir dipivoxil is classified as a nucleoside analogue and is part of the antiviral drug class, making it an important option in the management of HBV, especially in patients who are resistant to other therapies.
Formula:C20H32N5O8P
InChI:InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChI key:InChIKey=WOZSCQDILHKSGG-UHFFFAOYSA-N
SMILES:O=C(OCOP(=O)(OCOC(=O)C(C)(C)C)COCCN1C=NC=2C(=NC=NC21)N)C(C)(C)C
- Synonyms:
- 3-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-8,8-dimethyl-3-oxido-7-oxo-2,4,6-trioxa-3lambda~5~-phosphanon-1-yl 2,2-dimethylpropanoate
- 9-[2-[Bis[(Pivaloyloxy)Methoxy]Phosphinyl]Methoxy]Ethyl]Adenine
- Adefovir Dipivoxl
- Adefovir Pivoxil
- Adefovir dipivoxil
- Gs 0840
- Hepsera
- Preveon
- Propanoic acid, 2,2-dimethyl-, 1,1′-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester
- Propanoic acid, 2,2-dimethyl-, [[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene) ester
- See more synonyms
- [2-(6-Aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
- bis(POM)-PMEA
