CAS 142340-99-6

Adefovir dipivoxil

Description:

Adefovir dipivoxil is an antiviral medication primarily used in the treatment of chronic hepatitis B virus (HBV) infection. It is a prodrug of adefovir, which means it is converted into its active form in the body. The compound is characterized by its ability to inhibit viral DNA polymerase, thereby preventing the replication of the virus. Adefovir dipivoxil is typically administered orally and is known for its relatively low toxicity profile compared to other antiviral agents. Its chemical structure includes a phosphonate group, which contributes to its mechanism of action. The substance is soluble in water and exhibits stability under physiological conditions. Common side effects may include nephrotoxicity and gastrointestinal disturbances, necessitating monitoring of renal function during treatment. Adefovir dipivoxil is classified as a nucleoside analogue and is part of the antiviral drug class, making it an important option in the management of HBV, especially in patients who are resistant to other therapies.

Formula: C₂₀H₃₂N₅O₈P

InChI: InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)

InChI key: InChIKey=WOZSCQDILHKSGG-UHFFFAOYSA-N

SMILES: C(COCP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)N1C=2C(N=C1)=C(N)N=CN2

Synonyms:

• 3-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-8,8-dimethyl-3-oxido-7-oxo-2,4,6-trioxa-3lambda~5~-phosphanon-1-yl 2,2-dimethylpropanoate
• 9-[2-[Bis[(Pivaloyloxy)Methoxy]Phosphinyl]Methoxy]Ethyl]Adenine
• Adefovir Dipivoxl
• Adefovir Pivoxil
• Adefovir dipivoxil
• Gs 0840
• Hepsera
• Preveon
• Propanoic acid, 2,2-dimethyl-, 1,1′-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester
• Propanoic acid, 2,2-dimethyl-, [[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene) ester
• [2-(6-Aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

Adefovir Dipivoxil

CAS: 142340-99-6

Formula: C₂₀H₃₂N₅O₈P

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 501.48

Ref: 3B-A2414

Adefovir Dipivoxil

CAS: 142340-99-6

Formula: C₂₀H₃₂N₅O₈P

Purity: 98%

Color and Shape: Solid

Molecular weight: 501.4705

Ref: IN-DA007YTX

Adefovir dipivoxil

CAS: 142340-99-6

Formula: C₂₀H₃₂N₅O₈P

Purity: ≥ 98.0%

Color and Shape: White to almost white powder or crystalline powder

Molecular weight: 501.47

Ref: 7W-GP5823

Adefovir dipivoxil

CAS: 142340-99-6

Adefovir dipivoxil

Purity: ≥98%

Molecular weight: 501.47g/mol

Ref: 54-BUP15791

Adefovir Dipivoxil

CAS: 142340-99-6

Adefovir Dipivoxil

Purity: 99%

Molecular weight: 501.47g/mol

Ref: 54-OR1030076

Adefovir Dipivoxil

CAS: 142340-99-6

Formula: C₂₀H₃₂N₅O₈P

Color and Shape: White To Off-White Solid

Molecular weight: 501.48

Ref: 4Z-A-363

Adefovir dipivoxil 100 µg/mL in Acetonitrile

CAS: 142340-99-6

Formula: C₂₀H₃₂N₅O₈P

Color and Shape: Single Solution

Molecular weight: 501.47

Ref: 04-A10045805AL-100

Adefovir Dipivoxil

Controlled Product

CAS: 142340-99-6

Formula: C₂₀H₃₂N₅O₈P

Color and Shape: Neat

Molecular weight: 501.47

Ref: 86-MM3505.00

Adefovir dipivoxil

CAS: 142340-99-6

Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against

Formula: C₂₀H₃₂N₅O₈P

Purity: 98% - 99.80%

Color and Shape: It Has Broad-Spectrum Antiviral Activity

Molecular weight: 501.47

Ref: TM-T1675

Adefovir Dipivoxil

Controlled Product

CAS: 142340-99-6

Applications A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI).
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010), Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010),

Formula: C₂₀H₃₂N₅O₈P

Color and Shape: Neat

Molecular weight: 501.47

Ref: TR-A280465

Adefovir dipivoxil - Bio-X ™

CAS: 142340-99-6

Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analogue that works by blocking reverse transcriptase. This drug is used to treat infections associated with Hepatitis B.

Formula: C₂₀H₃₂N₅O₈P

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 501.47 g/mol

Ref: 3D-BA164139

Adefovir dipivoxil

CAS: 142340-99-6

Anti-viral; reverse transcriptase inhibitor

Formula: C₂₀H₃₂N₅O₈P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 501.47 g/mol

Ref: 3D-FA07057

ADEFOVIR DIPIVOXIL

CAS: 142340-99-6

Purity: ≥99%

Molecular weight: 501.4769897

Ref: 10-F857130