CAS 142341-05-7

[[[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl 2,2-dimethylpropanoate

Description:

The chemical substance with the name "[[[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl 2,2-dimethylpropanoate" and CAS number 142341-05-7 is a complex organic compound that features a purine base, specifically 6-amino-9H-purine, which is a derivative of adenine. This compound contains a phosphinyl group, indicating it has phosphorus in its structure, which is often associated with biological activity, particularly in the context of nucleotides and nucleic acids. The presence of an ethoxy group suggests it may have solubility in organic solvents, while the dimethylpropanoate moiety could contribute to its lipophilicity. The hydroxyl and methoxy functionalities imply potential for hydrogen bonding, which may influence its reactivity and interactions with biological targets. Overall, this compound may exhibit properties relevant to medicinal chemistry, particularly in the development of pharmaceuticals targeting nucleic acid synthesis or modification. Further studies would be necessary to elucidate its specific biological activities and potential applications.

Formula: C₁₄H₂₂N₅O₆P

InChI: InChI=1S/C14H22N5O6P/c1-14(2,3)13(20)24-8-25-26(21,22)9-23-5-4-19-7-18-10-11(15)16-6-17-12(10)19/h6-7H,4-5,8-9H2,1-3H3,(H,21,22)(H2,15,16,17)

InChI key: InChIKey=MYHVYLHIHRHSDC-UHFFFAOYSA-N

SMILES: C(COCP(OCOC(C(C)(C)C)=O)(=O)O)N1C=2C(N=C1)=C(N)N=CN2

Synonyms:

• ((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)(hydroxy)phosphoryl)oxy)methyl pivalate
• Adefovir Monopivoxil
• Mono(POM)-PMEA
• Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl ester
• [[[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl 2,2-dimethylpropanoate

Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl ester

CAS: 142341-05-7

Formula: C₁₄H₂₂N₅O₆P

Color and Shape: Solid

Molecular weight: 387.3281

Ref: IN-DA009BC5

Adefovir Dipivoxyl Impurity A

CAS: 142341-05-7

Formula: C₁₄H₂₂N₅O₆P

Color and Shape: White To Off-White Solid

Molecular weight: 387.33

Ref: 4Z-A-364

Adefovir Monopivoxil

Controlled Product

CAS: 142341-05-7

Applications The monoester metabolite of the adefovir prodrug Adefovir Dipivoxil (A280465).
References Shaw, J.-P. et al.: Drug Metab. Dispos., 25, 362 (1997); Annaert, P. et al.: Pharmac. res., 15, 1168 (1998); Annaert, P. et al.: J. Pharmac. Sci., 89, 1054 (2000);

Formula: C₁₄H₂₂N₅O₆P

Color and Shape: Beige Solid

Molecular weight: 387.33

Ref: TR-A247525

Adefovir Monopivoxil

CAS: 142341-05-7

Adefovir Monopivoxil is a prodrug that is converted to adefovir, an antiviral drug, in the body. The preparation process of Adefovir Monopivoxil is based on the basic research of adefovir and its efficiency was proved by reproducible experiments. It has been shown that Adefovir Monopivoxil can inhibit the growth of viruses by inhibiting the synthesis of virus-specific single-stranded DNA or RNA in infected cells. It also has low bioavailability, which may be due to alkylene groups that cause slow absorption from the gastrointestinal tract. Adefovir Monopivoxil is orally active and can be used for treatment of chronic hepatitis B virus infection.

Formula: C₁₄H₂₂N₅O₆P

Purity: Min. 95%

Molecular weight: 387.33 g/mol

Ref: 3D-SFA34105

Adefovir Monopivoxil

CAS: 142341-05-7

Formula: C₁₄H₂₂N₅O₆P

Molecular weight: 387.33

Ref: ST-EA-CP-A172019