CAS 142375-60-8

FR 139317

Description:

FR 139317, with the CAS number 142375-60-8, is a chemical compound primarily recognized for its role as a selective antagonist of the neuropeptide Y (NPY) Y1 receptor. This compound is of interest in pharmacological research, particularly in the context of obesity and metabolic disorders, as it may influence appetite regulation and energy balance. FR 139317 exhibits a high degree of specificity for the Y1 receptor, making it a valuable tool for studying the physiological effects of NPY signaling. In terms of its physical properties, FR 139317 is typically characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. The compound is often evaluated in preclinical studies to assess its efficacy and safety profile. As with many research chemicals, handling and usage require adherence to safety protocols to mitigate any potential risks associated with exposure.

Formula: C₃₃H₄₄N₆O₅

InChI: InChI=1/C33H44N6O5/c1-22(2)18-26(37-33(44)39-16-10-4-5-11-17-39)30(40)35-27(19-23-21-38(3)29-14-7-6-13-25(23)29)31(41)36-28(32(42)43)20-24-12-8-9-15-34-24/h6-9,12-15,21-22,26-28H,4-5,10-11,16-20H2,1-3H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/t26-,27+,28+/m0/s1

InChI key: InChIKey=LIOKMIQQPDDTNO-UPRLRBBYSA-N

SMILES: C([C@@H](NC([C@@H](NC(=O)N1CCCCCC1)CC(C)C)=O)C(N[C@H](CC2=CC=CC=N2)C(O)=O)=O)C=3C=4C(N(C)C3)=CC=CC4

Synonyms:

• <span class="text-smallcaps">D</smallcap>-Alanine, N-[(hexahydro-1H-azepin-1-yl)carbonyl]-<smallcap>L</smallcap>-leucyl-1-methyl-<smallcap>D</span>-tryptophyl-3-(2-pyridinyl)-
• <span class="text-smallcaps">D</smallcap>-Alanine, N-[N-[N-[(hexahydro-1H-azepin-1-yl)carbonyl]-<smallcap>L</smallcap>-leucyl]-1-methyl-<smallcap>D</span>-tryptophyl]-3-(2-pyridinyl)-
• Fr 139317
• N-(azepan-1-ylcarbonyl)-L-leucyl-1-methyl-D-tryptophyl-3-pyridin-2-yl-D-alanine
• N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-<span class="text-smallcaps">L</smallcap>-leucyl-1-methyl-<smallcap>D</smallcap>-tryptophyl-3-(2-pyridinyl)-<smallcap>D</span>-alanine
• Pd 147953
• D-Alanine, N-[N-[N-[(hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-3-(2-pyridinyl)-
• N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-D-alanine
• D-Alanine, N-[(hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-
• N-[N-[N-[(HEXAHYDRO-1H-AZEPIN-1-YL)CARBONYL]-L-LEUCYL]-1-METHYL-D-TRYPTOPHYL]-3-(2-PYRIDINYL)-D-ALANINE
• (2R)-2-[[(2R)-2-[[(2S)-2-(AZEPANE-1-CARBONYLAMINO)-4-METHYLPENTANOYL]AMINO]-3-(1-METHYLINDOL-3-YL)PROPANOYL]AMINO]-3-PYRIDIN-2-YLPROPANOIC ACID
• 2-((1-(Hexahydro-1H-azepinyl)carbonyl)amino-4-methylpentanoyl)-3-(-(1-methyl-1H-indolyl)propionyl)amino-3-(2-pyridyl)propionic acid
• N,N-hexamethylenecarbamoyl-leu-N-*methyl-D-trp-D-
• FR139317,CID107810
• (HEXAHYDRO-1H-AZEPINYL)CARBONYL-LEU-DTRP(ME)-D-ALA(2-PYRIDYL)-OH
• (HEXAHYDRO-1H-AZEPINYL)CARBONYL-LEU-D-(1-ME)-TRP-DPAL

FR 139317

CAS: 142375-60-8

Formula: C₃₃H₄₄N₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 604.7397

Ref: IN-DA01ENF8

FR 139317

Controlled Product

CAS: 142375-60-8

FR 139317 is a selective endothelin receptor antagonist that binds to the endothelin-A receptor, inhibiting its activity. It has been shown to reduce myocardial infarct size and improve cardiac function in an animal model of myocardial infarct. FR 139317 also inhibits the growth of pulmonary artery smooth muscle cells in vitro and reduces endothelin-1 levels in a rat model of primary pulmonary hypertension. This drug also leads to an increase in natriuretic peptide levels and disease activity, as well as decreased blood pressure in rats with renal failure.

Formula: C₃₃H₄₄N₆O₅

Purity: Min. 95%

Molecular weight: 604.75 g/mol

Ref: 3D-SFA37560

FR 139317

CAS: 142375-60-8

highly potent and selective ETA endothelin receptor antagonist

Formula: C₃₃H₄₄N₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 604.74

Ref: TM-T22791