CAS 142382-16-9
:Rapamycin, 41-O-demethyl-
Description:
Rapamycin, 41-O-demethyl- (CAS 142382-16-9) is a derivative of rapamycin, a macrolide compound originally discovered as an antifungal agent. This substance exhibits immunosuppressive properties, making it valuable in preventing organ transplant rejection and in treating certain cancers. Its mechanism of action primarily involves the inhibition of the mTOR (mechanistic target of rapamycin) pathway, which plays a crucial role in cell growth, proliferation, and survival. The chemical structure of 41-O-demethyl-rapamycin features a modified lactone ring, which alters its pharmacological profile compared to its parent compound. This modification can influence its solubility, bioavailability, and potency. Additionally, rapamycin and its derivatives are being investigated for their potential in age-related diseases and metabolic disorders due to their effects on cellular senescence and autophagy. As with many pharmacologically active compounds, careful consideration of dosage and potential side effects is essential in clinical applications. Overall, 41-O-demethyl-rapamycin represents a significant area of research in both therapeutic and biomedical fields.
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