CAS 14255-87-9

Parbendazole

Description:

Parbendazole is a benzimidazole derivative primarily used as an anthelmintic agent, effective against a variety of parasitic worms. It is characterized by its broad-spectrum activity, making it valuable in veterinary medicine for treating infections in livestock. The chemical structure of parbendazole features a benzimidazole core, which is crucial for its mechanism of action, as it disrupts the microtubule formation in parasites, leading to their immobilization and death. Parbendazole is typically administered orally and is known for its relatively low toxicity in target animals. Its solubility profile indicates that it is more soluble in organic solvents than in water, which can influence its bioavailability and absorption. Additionally, parbendazole is often studied for its potential effects on human health, particularly in relation to its metabolites and environmental impact. As with many pharmaceuticals, proper handling and dosage are essential to maximize efficacy while minimizing adverse effects.

Formula: C₁₃H₁₇N₃O₂

InChI: InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)

InChI key: InChIKey=YRWLZFXJFBZBEY-UHFFFAOYSA-N

SMILES: N(C(OC)=O)C=1NC=2C(N1)=CC(CCCC)=CC2

Synonyms:

• 2-Benzimidazolecarbamic acid, 5-butyl-, methyl ester
• 5-Butyl-2-(carbomethoxyamino)benzimidazole
• Carbamic acid, (5-butyl-1H-benzimidazol-2-yl)-, methyl ester
• Carbamic acid, N-(6-butyl-1H-benzimidazol-2-yl)-, methyl ester
• Helatac
• Helmatac
• Methyl (5-butyl-1H-benzimidazol-2-yl)carbamate
• Methyl 5(6)-butyl-2-benzimidazolecarbamate
• Methyl 5-butylbenzimidazole-2-carbamate
• PBZ (fungicide)
• Skf 29044
• methyl (6-butyl-1H-benzimidazol-2-yl)carbamate
• methyl N-(5-butyl-3H-benzoimidazol-2-yl)carbamate

Parbendazole

CAS: 14255-87-9

Color and Shape: Neat

Ref: 61-FOR0892.00

Parbendazole

CAS: 14255-87-9

Anti-infective agents, nesoi

Formula: C₁₃H₁₇N₃O₂

Color and Shape: White Fine Powder Crystals

Molecular weight: 247.13208

Ref: 45-1498706

Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate

CAS: 14255-87-9

Formula: C₁₃H₁₇N₃O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 247.2930

Ref: IN-DA00392H

Parbendazole

CAS: 14255-87-9

Parbendazole

Purity: ≥95%

Molecular weight: 247.29g/mol

Ref: 54-BUP11277

Methyl (5-butyl-1H-benzimidazol-2-yl)carbamate

CAS: 14255-87-9

Methyl (5-butyl-1H-benzimidazol-2-yl)carbamate

Formula: C₁₃H₁₇N₃O₂

Purity: 95%

Color and Shape: faint beige solid

Molecular weight: 247.29g/mol

Ref: 54-OR305450

Parbendazole

CAS: 14255-87-9

Formula: C₁₃H₁₇N₃O₂

Color and Shape: Off-White Solid

Molecular weight: 247.30

Ref: 4Z-P-203001

Parbendazole

CAS: 14255-87-9

Formula: C₁₃H₁₇N₃O₂

Color and Shape: Neat

Molecular weight: 247.29

Ref: 04-C15892000

Parbendazole-d3

CAS: 14255-87-9

Formula: C₁₃H₁₄N₃O₂D₃

Molecular weight: 250.32

Ref: 4Z-P-203002

Parbendazole

CAS: 14255-87-9

Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.

Formula: C₁₃H₁₇N₃O₂

Purity: 99.60%

Color and Shape: Physical Description Crystals Or Fine White Powder (Ntp 1992)

Molecular weight: 247.29

Ref: TM-T6071

Parbendazole

Controlled Product

CAS: 14255-87-9

Applications Parbendazole is a benzimidazole carbamate and a potent inhibitor of microtubule assembly and functions.
References Lahon, L.C.. et al.: Ind. J. Pharmacol., 26, 235 (1994); Havercroft, J.C., et al.: J. Cell. Sci., 49, 195 (1981);

Formula: C₁₃H₁₇N₃O₂

Color and Shape: Neat

Molecular weight: 247.29

Ref: TR-P193260

Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate

CAS: 14255-87-9

Formula: C₁₃H₁₇N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 247.298

Ref: 10-F319850

Parbendazole

CAS: 14255-87-9

Parbendazole is a carbonyl-containing drug that has been used in cancer chemotherapy. It is an anthelmintic drug that has minimal toxicity and has also shown to inhibit the growth of leukemic stem cells. Parbendazole inhibits the synthesis of ATP by targeting the mitochondrial electron transport chain. It binds to the cytochrome c1-c6 complex, which prevents release of electrons from cytochrome c1 to oxygen and leads to inhibition of oxidative phosphorylation. Parbendazole also exhibits inhibitory properties against leukemia stem cells, which may be due to its ability to decrease the expression of CD133 on these cells.

Formula: C₁₃H₁₇N₃O₂

Purity: Min. 95%

Molecular weight: 247.29 g/mol

Ref: 3D-PAA25587