CAS 14259-58-6

5′-Deoxy-5′-iodouridine

Description:

5′-Deoxy-5′-iodouridine, with the CAS number 14259-58-6, is a nucleoside analog characterized by the presence of an iodine atom at the 5′ position of the sugar moiety. This compound is derived from uridine, where the hydroxyl group at the 5′ carbon is replaced by an iodine atom, resulting in a modified structure that can influence its biological activity. It is typically used in biochemical research and has potential applications in antiviral and anticancer therapies due to its ability to interfere with nucleic acid synthesis. The presence of the iodine atom can enhance the compound's stability and alter its interaction with enzymes and nucleic acids. Additionally, 5′-Deoxy-5′-iodouridine may exhibit unique solubility and reactivity properties compared to its non-iodinated counterparts. As a nucleoside analog, it can be incorporated into RNA or DNA, potentially leading to mutations or inhibition of viral replication, making it a subject of interest in medicinal chemistry and pharmacology.

Formula: C₉H₁₁IN₂O₅

InChI: InChI=1S/C9H11IN2O5/c10-3-4-6(14)7(15)8(17-4)12-2-1-5(13)11-9(12)16/h1-2,4,6-8,14-15H,3H2,(H,11,13,16)/t4-,6-,7-,8-/m1/s1

InChI key: InChIKey=NEMNIUYGXIQPPK-XVFCMESISA-N

SMILES: O[C@H]1[C@@H](O[C@H](CI)[C@H]1O)N2C(=O)NC(=O)C=C2

Synonyms:

• 5'-Iodo-2'deoxyuridine
• 5′-Iodo-5′-deoxyuridine
• Uridine, 5'-deoxy-5'-iodo-
• 5′-Deoxy-5′-iodouridine
• 5'-Deoxy-5'-iodouridine

5'-Deoxy-5'-iodouridine

CAS: 14259-58-6

Formula: C₉H₁₁IN₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 354.0985

Ref: IN-DA009CFH

5'-Deoxy-5'-iodouridine

CAS: 14259-58-6

5'-Deoxy-5'-iodouridine

Purity: 95%

Molecular weight: 354.1g/mol

Ref: 54-OR1006676

5'-Deoxy-5'-iodouridine

CAS: 14259-58-6

Nucleoside Derivatives - Halo-nucleosides, 5’-Modified nucleosides

Formula: C₉H₁₁IN₂O₅

Color and Shape: Solid

Molecular weight: 354.1

Ref: TM-TNU0886

5′-DEOXY-5′-IODOURIDINE

CAS: 14259-58-6

Formula: C₉H₁₁IN₂O₅

Purity: 95%

Molecular weight: 354.1

Ref: 10-F512993

5’-Deoxy-5’-iodouridine

CAS: 14259-58-6

5’-Deoxy-5’-iodouridine (5DIU) is an antiviral agent that inhibits the synthesis of DNA by interfering with the enzyme thymidine kinase, which converts thymine to uracil. It is used in the treatment of cutaneous herpes simplex virus infections. 5DIU has been shown to inhibit viral replication and yield in vitro. The drug showed no significant toxicity in mice, rats, or hamsters. In addition, it has been observed that 5DIU does not interfere with human cell growth, which may be due to its lack of activity against a wide range of human enzymes.

Purity: Min. 95%

Ref: 3D-ND144937