RORγt-IN-9a is a synthetic compound that acts as an inverse agonist for the retinoic acid receptor-related orphan receptor gamma t (RORγt), a nuclear receptor that plays a crucial role in the regulation of immune responses, particularly in the differentiation of T helper 17 (Th17) cells. This compound is of interest in the field of immunology and pharmacology due to its potential therapeutic applications in autoimmune diseases and inflammatory conditions. RORγt-IN-9a is characterized by its ability to modulate gene expression linked to immune function, thereby influencing the inflammatory response. The compound's structure typically includes specific functional groups that enhance its binding affinity and selectivity for the RORγt receptor. As a research chemical, it is primarily used in laboratory settings to study the mechanisms of immune regulation and to explore new treatment avenues for diseases associated with Th17 cell activity. Safety and handling guidelines should be followed, as with all chemical substances, to ensure proper usage in research environments.

RORγt-IN-9a

1426803-07-7: RORγt-IN-9a is a synthetic compound that acts as an inverse agonist for the retinoic acid receptor-related orphan receptor gamma t (RORγt), a nuclear receptor that plays a crucial role in the regulation of immune responses, particularly in the differentiation of T helper 17 (Th17) cells. This compound is of interest in the field of immunology and pharmacology due to its potential therapeutic applications in autoimmune diseases and inflammatory conditions. RORγt-IN-9a is characterized by its ability to modulate gene expression linked to immune function, thereby influencing the inflammatory response. The compound's structure typically includes specific functional groups that enhance its binding affinity and selectivity for the RORγt receptor. As a research chemical, it is primarily used in laboratory settings to study the mechanisms of immune regulation and to explore new treatment avenues for diseases associated with Th17 cell activity. Safety and handling guidelines should be followed, as with all chemical substances, to ensure proper usage in research environments.

<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>

CAS 1426803-07-7

RORγt-IN-9a

RORγt inhibitor 4

Ref: TM-T205045