CAS 1428-95-1

Hexamethylene amiloride

Description:

Hexamethylene amiloride, with the CAS number 1428-95-1, is a synthetic compound that belongs to the class of amiloride derivatives. It is characterized by its structural features, which include a hexamethylene chain and an amiloride moiety, contributing to its biological activity. This compound is primarily recognized for its role as a potassium-sparing diuretic, functioning by inhibiting epithelial sodium channels in the renal tubules, thereby promoting sodium excretion while conserving potassium. Hexamethylene amiloride exhibits moderate solubility in water and is typically stable under standard laboratory conditions. Its pharmacological properties make it of interest in research related to hypertension and fluid balance disorders. Additionally, the compound's interactions with various biological systems highlight its potential therapeutic applications, although further studies are necessary to fully elucidate its efficacy and safety profiles. As with many chemical substances, proper handling and safety precautions are essential due to its biological activity and potential effects on human health.

Formula: C₁₂H₁₈ClN₇O

InChI: InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)

InChI key: InChIKey=RQQJJXVETXFINY-UHFFFAOYSA-N

SMILES: ClC=1C(=NC(N)=C(C(NC(=N)N)=O)N1)N2CCCCCC2

Synonyms:

• 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-
• 3-Amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide
• 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-2-pyrazinecarboxamide
• 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)pyrazinecarboxamide
• 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
• 5-(N,N-Hexamethylene)amiloride
• 5-Hexamethylene amiloride
• Hexamethylene amiloride
• Hexamethyleneamiloride
• Hma-5
• Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-

5-(N,N-Hexamethylene)amiloride

CAS: 1428-95-1

Formula: C₁₂H₁₈ClN₇O

Molecular weight: 311.77

Ref: 7W-GK7778

5-(N,N-Hexamethylene)-amiloride

CAS: 1428-95-1

5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.

Formula: C₁₂H₁₈ClN₇O

Purity: 85.48%

Color and Shape: Solid

Molecular weight: 311.77

Ref: TM-T4699