CAS 1428327-31-4

JNJ-47965567

CAS: 1428327-31-4

Formula: C₂₈H₃₂N₄O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 488.6443

Ref: IN-DA01C15W

N-((4-(4-Phenylpiperazin-1-Yl)Tetrahydro-2H-Pyran-4-Yl)Methyl)-2-(Phenylthio)Nicotinamide

CAS: 1428327-31-4

N-((4-(4-Phenylpiperazin-1-Yl)Tetrahydro-2H-Pyran-4-Yl)Methyl)-2-(Phenylthio)Nicotinamide

Purity: 99%

Molecular weight: 488.64g/mol

Ref: 54-OR1026005

JNJ-47965567

CAS: 1428327-31-4

JNJ-47965567

Purity: ≥98%

Molecular weight: 488.64g/mol

Ref: 54-BUP09536

JNJ-47965567

CAS: 1428327-31-4

JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for

Formula: C₂₈H₃₂N₄O₂S

Purity: 99.11%

Color and Shape: Solid

Molecular weight: 488.64

Ref: TM-T4298

N-((4-(4-PHENYLPIPERAZIN-1-YL)TETRAHYDRO-2H-PYRAN-4-YL)METHYL)-2-(PHENYLTHIO)NICOTINAMIDE

CAS: 1428327-31-4

Purity: 98%

Molecular weight: 488.6499939

Ref: 10-F813677

JNJ-47965567

CAS: 1428327-31-4

JNJ-47965567 is a selective P2X7 receptor antagonist, which is derived from a rigorous screening of chemical libraries to target purinergic signaling pathways. Its mode of action involves competitive inhibition of the P2X7 receptor, a ligand-gated ion channel activated by extracellular ATP. This receptor is predominantly expressed in immune cells and is implicated in the release of pro-inflammatory cytokines.The primary applications of JNJ-47965567 lie in its potential therapeutic role in conditions where excessive inflammation is a contributing factor. Specifically, it is studied for its ability to modulate immune responses, with implications in autoimmune diseases, neurodegenerative disorders, and chronic pain. The specificity and efficacy of JNJ-47965567 as an antagonist allow it to serve as a valuable tool in elucidating P2X7 receptor function and its involvement in pathological processes. Research involving JNJ-47965567 continues to probe its pharmacodynamics and possible integration into therapeutic strategies targeting inflammation-driven diseases.

Formula: C₂₈H₃₂N₄O₂S

Purity: Min. 95%

Molecular weight: 488.64 g/mol

Ref: 3D-DHC32731