CAS 142880-36-2

Ilomastat

Description:

Ilomastat, also known by its chemical name, is a synthetic compound classified as a matrix metalloproteinase (MMP) inhibitor. It is primarily researched for its potential therapeutic applications in treating various diseases, including cancer and fibrotic conditions. The substance works by inhibiting the activity of MMPs, which are enzymes involved in the degradation of extracellular matrix components, thereby influencing tissue remodeling and repair processes. Ilomastat has been studied for its ability to reduce tumor invasion and metastasis by limiting the breakdown of the extracellular matrix. In terms of its physical properties, Ilomastat is typically characterized by its specific molecular structure, which includes functional groups that contribute to its biological activity. The compound is usually administered in a controlled manner in clinical settings, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its efficacy and safety profile. Ongoing research continues to explore its full potential and mechanisms of action in various therapeutic contexts.

Formula: C₂₀H₂₈N₄O₄

InChI: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

InChI key: InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N

SMILES: C([C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C(NC)=O)C=1C=2C(NC1)=CC=CC2

Synonyms:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• (2R)-N~4~-hydroxy-N~1~-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
• (R)-N1-((S)-3-(1H-indol-3yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-Indol-3-Yl)-1-Methylcarbamoly-Ethyl]-2-Isobutyl-Succinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-
• Cs 610
• Galardin
• Galardin Tm
• Galardin, GM6001, Ilomastat
• Gm 6001
• Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

Illomastat

CAS: 142880-36-2

Formula: C₂₀H₂₈N₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 388.4607

Ref: IN-DA00350G

Ilomastat

CAS: 142880-36-2

Ilomastat

Purity: ≥95%

Molecular weight: 388.46g/mol

Ref: 54-BUP12328

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

CAS: 142880-36-2

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide

Purity: 98%

Molecular weight: 388.46g/mol

Ref: 54-OR1023104

Ilomastat

CAS: 142880-36-2

Formula: C₂₀H₂₈N₄O₄

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 388.47

Ref: 3B-I1202

Ilomastat

CAS: 142880-36-2

Formula: C₂₀H₂₈N₄O₄

Molecular weight: 388.50

Ref: 7W-GK4753

Ilomastat

CAS: 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Formula: C₂₀H₂₈N₄O₄

Purity: 97.04% - 99.51%

Color and Shape: Solid

Molecular weight: 388.46

Ref: TM-T2743

Ilomastat

Controlled Product

CAS: 142880-36-2

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Formula: C₂₀H₂₈N₄O₄

Color and Shape: Neat

Molecular weight: 388.46

Ref: TR-I267180

Galardinᵀᴹ

CAS: 142880-36-2

Galardinâ„¢ is an experimental drug with inhibitory properties, which can be used as a potential drug target to treat various diseases. It inhibits the polymerase chain reaction by binding to the enzyme DNA polymerase and preventing its activity. Galardinâ„¢ also has been shown to have protective effects against oxidative injury in 3T3-L1 preadipocytes and protect cells from cell death by inhibiting toll-like receptor signaling pathways. In addition, it has antimicrobial activity against Candida glabrata and other bacterial strains, such as Staphylococcus aureus and Acinetobacter baumannii.

Formula: C₂₀H₂₈N₄O₄

Purity: Min. 95%

Molecular weight: 388.47 g/mol

Ref: 3D-INH-3927-PI

(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

CAS: 142880-36-2

Purity: 95%+

Molecular weight: 388.4679871

Ref: 10-F868898

GM 6001

CAS: 142880-36-2

GM 6001 is a matrix that contains benzalkonium chloride. It is used as a pharmacological agent to prevent the growth of bacteria, fungi, and viruses. This product inhibits the synthesis of proteins that are required for cell division and may cause neuronal death. GM 6001 has been shown to inhibit the expression of matrix metalloproteinase-9 (MMP-9) in cultured cells, which may be due to its interference with the synthesis of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α). GM 6001 also has potent immunosuppressive properties by inhibiting toll-like receptors (TLRs) in macrophages and dendritic cells. The TLRs are important for initiating immune responses against pathogens.

Formula: C₂₀H₂₈N₄O₄

Purity: Min. 95%

Molecular weight: 388.46 g/mol

Ref: 3D-SFA88036