CAS 142880-36-2: Ilomastat

Description: Ilomastat, also known by its chemical name, is a synthetic compound classified as a matrix metalloproteinase (MMP) inhibitor. It is primarily researched for its potential therapeutic applications in treating various diseases, including cancer and fibrotic conditions. The substance works by inhibiting the activity of MMPs, which are enzymes involved in the degradation of extracellular matrix components, thereby influencing tissue remodeling and repair processes. Ilomastat has been studied for its ability to reduce tumor invasion and metastasis by limiting the breakdown of the extracellular matrix. In terms of its physical properties, Ilomastat is typically characterized by its specific molecular structure, which includes functional groups that contribute to its biological activity. The compound is usually administered in a controlled manner in clinical settings, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its efficacy and safety profile. Ongoing research continues to explore its full potential and mechanisms of action in various therapeutic contexts.

Formula: C₂₀H₂₈N₄O₄

InChI: InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

InChI key: InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N

SMILES: O=C(NO)CC(C(=O)NC(C(=O)NC)CC1=CNC=2C=CC=CC21)CC(C)C

Synonyms:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• (2R)-N~4~-hydroxy-N~1~-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
• (R)-N1-((S)-3-(1H-indol-3yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-Indol-3-Yl)-1-Methylcarbamoly-Ethyl]-2-Isobutyl-Succinamide
• (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-
• Cs 610
• Galardin
• Galardin Tm
• Galardin, GM6001, Ilomastat
• Gm 6001
• Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
• (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• Butanediamide, N4-hydroxy-N1-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, [S-(R*,S*)]-

Illomastat

CAS: 142880-36-2

• Formula: C₂₀H₂₈N₄O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 388.4607

Ilomastat

CAS: 142880-36-2

• Formula: C₂₀H₂₈N₄O₄
• Purity: >95.0%(HPLC)(qNMR)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 388.47

Ilomastat

CAS: 142880-36-2

• Formula: C₂₀H₂₈N₄O₄
• Molecular weight: 388.50

Ilomastat

CAS: 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

• Formula: C₂₀H₂₈N₄O₄
• Purity: 97.04% - 99.51%
• Color and Shape: Solid
• Molecular weight: 388.46

Ilomastat

CAS: 142880-36-2

Applications Ilomastat is a metalloprotease inhibitor. References Dietrich, C., et. al.: J. Immunol., 192, 5382 …

• Formula: C₂₀H₂₈N₄O₄
• Color and Shape: Neat
• Molecular weight: 388.46

Galardinᵀᴹ

CAS: 142880-36-2

Galardinâ„¢ is an experimental drug with inhibitory properties, which can be used as a potential …

• Formula: C₂₀H₂₈N₄O₄
• Purity: Min. 95%
• Molecular weight: 388.47 g/mol

GM 6001

CAS: 142880-36-2

GM 6001 is a matrix that contains benzalkonium chloride. It is used as a pharmacological …

• Formula: C₂₀H₂₈N₄O₄
• Purity: Min. 95%
• Molecular weight: 388.46 g/mol