Inhibitor Enzymes

Applications Alectinib M4 metabolite is the major active metabolite of Alectinib. Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor and is used to treat non-​small-​cell lung cancer by blocking the activity of anaplastic lymphoma kinase (ALK).
References Heinig, K., et al.: Bioanalysis, 8, 1465-79 (2016); Morcos, P.N., et al.: Xenobiotica, 47, 217-29 (2017);

Applications Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 (F229005) which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.
References Du, J., et al.: Handbook of Metabolic Pathways of Xenobiotics, 4, 1395 (2014)

Stability Hygroscopic
Applications Quercetin Hydrate is a PI 3-kinase inhibitor, GPR30 activator, and apoptosis inducer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).
References Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003), Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2006), Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2008),