CAS 142926-07-6

O-Desmethyl Diltiazem Hydrochloride

Description:

O-Desmethyl Diltiazem Hydrochloride is a chemical compound that serves as a metabolite of the calcium channel blocker diltiazem, which is commonly used in the treatment of hypertension and angina. This substance is characterized by its molecular structure, which includes a benzothiazepine core, contributing to its pharmacological activity. It is typically presented as a white to off-white crystalline powder and is soluble in water and organic solvents, which facilitates its use in pharmaceutical formulations. The compound exhibits properties such as calcium channel inhibition, which helps in the relaxation of vascular smooth muscle and reduction of heart rate. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion, with a notable half-life that influences dosing regimens. As a hydrochloride salt, it enhances the stability and solubility of the compound. Safety and efficacy profiles are established through clinical studies, and it is essential to consider potential side effects and interactions with other medications when used therapeutically.

Formula: C₂₁H₂₅ClN₂O₄S

Synonyms:

• DiltiazeM EP IMpurity C
• Dilthiazem impurity C
• Diltiazem EP Impurity C (O-Desmethyl Diltiazem)
• O-Desmethyl Diltiazem Hydrochloride
• (2S-cis)-3-(Acetyloxy)-5-[2-(diMethylaMino)
• ethyl]-2,3-dihydro-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
• Diltiazem O-Desmethyl Hydrochloride
• (2S,3S)-3-(Acetyloxy)-5-[2-(diMethylaMino)ethyl]-2,3-dihydro-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
• (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-hydroxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate HCl
• Diltiazem Impurity 3(Diltiazem EP Impurity C)

O-Desmethyl Diltiazem Hydrochloride

Controlled Product

CAS: 142926-07-6

Impurity Diltiazem EP Impurity C (HCl)
Applications A metabolite of Diltiazem (D460620), an antianginal, antihypertensive pharmaceutical. Diltiazem EP Impurity C (HCl).
References Li, R., et al.: J. Med. Chem., 35, 3246 (1992),

Formula: C₂₁H₂₅ClN₂O₄S

Color and Shape: Neat

Molecular weight: 436.95

Ref: TR-D291605