CAS 142992-99-2

1-(3-nitrophenyl)guanidine nitrate

Description:

1-(3-Nitrophenyl)guanidine nitrate is a chemical compound characterized by its guanidine structure, which is modified by the presence of a nitrophenyl group and a nitrate moiety. This compound typically exhibits properties associated with both guanidine derivatives and nitro-substituted aromatic compounds. It is likely to be a crystalline solid at room temperature, with potential solubility in polar solvents due to the presence of the nitrate group. The nitrophenyl substituent may impart specific electronic and steric effects, influencing its reactivity and interactions with other chemical species. Additionally, compounds of this nature may exhibit biological activity, making them of interest in pharmaceutical research. Safety considerations are important, as nitro compounds can be sensitive to heat and shock, and guanidine derivatives may have specific toxicological profiles. Overall, 1-(3-nitrophenyl)guanidine nitrate is a compound that combines features of both organic and inorganic chemistry, with potential applications in various fields, including materials science and medicinal chemistry.

Formula: C₇H₉N₅O₅

InChI: InChI=1/C7H8N4O2.HNO3/c8-7(9)10-5-2-1-3-6(4-5)11(12)13;2-1(3)4/h1-4H,(H4,8,9,10);(H,2,3,4)

SMILES: c1cc(cc(c1)N(=O)=O)NC(=N)N.N(=O)(=O)O

3-Nitrophenylguanidine nitrate

CAS: 142992-99-2

3-Nitrophenylguanidine nitrate is a drug that targets the enzyme kinases, which are involved in the regulation of cell growth and division. It has been shown to inhibit the activity of stromal tumor cells, as well as chronic myeloid leukemia cells. 3-Nitrophenylguanidine nitrate inhibits protein synthesis by inhibiting demethylation and efflux, which enables imatinib to bind to the target site. This drug also has a rapid onset of action and can be used for monitoring chronic myeloid leukemia patients without the need for positron emission tomography (PET) scanning.

Formula: C₇H₈N₄O₂•HNO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 243.18 g/mol

Ref: 3D-FN26340

3-Nitrophenylguanidine Nitrate

Controlled Product

CAS: 142992-99-2

Applications Used for the preparation of N-thiazolpyrimidinyl-N-phenylamines as specific cyclin-dependent kinase inhibitors useful as antitumor agents.
References Buchdunger, E., et al.: J. Pharmacol. Exp. Ther., 295, 139 (2000), Szakacs, Z., et al.: J. Med. Chem., 48, 249 (2005), Pietras, K., et al.: Cancer Cell., 3, 439 (2003), Mahboobi, S., et al.: Eur. J. Med. Chem., 43, 1444 (2008),

Formula: C₇H₈N₄O₂

Color and Shape: Neat

Molecular weight: 180.16

Ref: TR-N503765