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CAS 143-57-7

:

protoveratrine

Description:
Protoveratrine is a complex alkaloid derived from the plant genus Veratrum, particularly from species such as Veratrum album and Veratrum viride. It is known for its potent pharmacological effects, primarily as a cardiovascular agent. Protoveratrine exhibits both vasodilatory and hypotensive properties, making it useful in the treatment of hypertension. The substance acts by blocking sodium channels and influencing calcium ion movement, which affects muscle contraction and vascular tone. It is typically found in the form of a white to off-white crystalline powder and is soluble in alcohol and slightly soluble in water. Due to its biological activity, protoveratrine can cause significant side effects, including nausea, vomiting, and cardiovascular disturbances, necessitating careful dosage and monitoring when used therapeutically. Its use has declined in favor of more modern antihypertensive agents, but it remains of interest in pharmacological research for its unique mechanisms of action. As with many alkaloids, safety and toxicity profiles are critical considerations in its application.
Formula:C41H63NO14
InChI:InChI=1/C41H63NO14/c1-10-20(4)34(46)55-33-28(45)27-23(18-42-17-19(3)12-13-25(42)38(27,9)49)24-16-39-32(40(24,33)50)30(53-22(6)44)29(52-21(5)43)31-36(39,7)15-14-26(41(31,51)56-39)54-35(47)37(8,48)11-2/h19-20,23-33,45,48-51H,10-18H2,1-9H3/t19-,20+,23-,24?,25-,26-,27+,28+,29-,30+,31-,32+,33-,36-,37?,38+,39-,40-,41-/m0/s1
InChI key:InChIKey=HYTGGNIMZXFORS-MGYKWWNKSA-N
SMILES:C[C@@]12[C@]34[C@]([C@@]5(O)[C@@](C3)([C@]6([C@]([C@@H](O)[C@@H]5OC([C@@H](CC)C)=O)([C@](C)(O)[C@]7(N(C6)C[C@@H](C)CC7)[H])[H])[H])[H])([C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]1([C@](O)(O4)[C@@H](OC([C@@](CC)(C)O)=O)CC2)[H])[H]
Synonyms:
  • (3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta)-4,9-Epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate) 15-(2-methylbutyrate)
  • (3beta,4alpha,6alpha,7alpha,9beta,12xi,15alpha,16beta)-6,7-bis(acetyloxy)-4,14,16,20-tetrahydroxy-15-{[(2R)-2-methylbutanoyl]oxy}-4,9-epoxycevan-3-yl 2-hydroxy-2-methylbutanoate
  • (3beta,4alpha,6alpha,7alpha,9beta,15alpha,16beta)-6,7-bis(acetyloxy)-4,14,16,20-tetrahydroxy-15-{[(2R)-2-methylbutanoyl]oxy}-4,9-epoxycevan-3-yl (2S)-2-hydroxy-2-methylbutanoate
  • (3beta,4alpha,6alpha,7alpha,9xi,15alpha,16beta)-6,7-bis(acetyloxy)-4,14,16,20-tetrahydroxy-15-{[(2R)-2-methylbutanoyl]oxy}-4,9-epoxycevan-3-yl (2S)-2-hydroxy-2-methylbutanoate
  • (4Beta,5Xi,7Beta,8Xi,10Alpha,12Xi,13Xi,14Beta,15Beta,16Alpha,17Xi,20Beta,22Xi,25Xi)-6,7-Bis(Acetyloxy)-4,14,16,20-Tetrahydroxy-15-[(2-Methylbutanoyl)Oxy]-4,9-Epoxycevan-3-Yl 2-Hydroxy-2-Methylbutanoate
  • 2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine, cevane-3,4,6,7,14,15,16,20-octol deriv.
  • Brn 0077415
  • Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate) 15-(2-methylbutanoate), (3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta)- (9CI)
  • Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate) 15-(2-methylbutanoate), [3β(S),4α,6α,7α,15α(R),16β]-
  • Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-[(2S)-2-hydroxy-2-methylbutanoate] 15-[(2R)-2-methylbutanoate], (3β,4α,6α,7α,15α,16β)-
  • See more synonyms
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Found 2 products.
  • Protoveratrine a
    Phytolab
    + Info

    Protoveratrine a

    CAS:
    Natural alkaloid
    Formula:C41H63NO14
    Purity:≥ 90.0 % (HPLC)
    Color and Shape:Powder
    Molecular weight:793.95

    Ref: 5G-89336

    10mg
    377.00€
    50mg
    1,637.00€
    250mg
    7,727.00€
    500mg
    14,545.00€
    1000mg
    27,272.00€
  • Protoveratrine
    Biosynth
    + Info

    Protoveratrine

    CAS:
    Protoveratrine is a potent alkaloid compound, which is derived from the roots and rhizomes of plants in the Veratrum genus, also known as false hellebores. It operates by interfering with sodium ion channels in the nervous and cardiovascular systems, leading to prolonged depolarization, thereby affecting normal cellular excitability and signal transmission.
    Formula:C41H63NO14
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:793.94 g/mol

    Ref: 3D-FP76725

    5mg
    863.00€
    10mg
    1,356.00€