Immunoglobulin G1 (IgG1) is a subclass of immunoglobulin that plays a crucial role in the immune response, particularly in recognizing and neutralizing pathogens. The specific compound you mentioned, anti-(human macrophage migration inhibitory factor) (MIF), is a human monoclonal antibody that targets MIF, a cytokine involved in inflammatory responses and immune regulation. The dimeric structure indicates that this antibody is formed by two linked chains: a γ1 heavy chain and a κ light chain, connected by disulfide bonds, which are essential for maintaining the stability and functionality of the antibody. This dimeric form enhances the binding affinity and specificity to its target, making it a valuable tool in therapeutic applications, particularly in conditions where MIF is implicated, such as autoimmune diseases and cancer. The CAS number 1430205-07-4 uniquely identifies this specific antibody, facilitating its recognition in scientific literature and regulatory contexts. Overall, this compound exemplifies the intricate design of monoclonal antibodies in targeting specific proteins for therapeutic interventions.

Immunoglobulin G1, anti-(human macrophage migration inhibitory factor) (human monoclonal BAX069 γ1-chain), disulfide with human monoclonal BAX069 κ-chain, dimer

1430205-07-4: Immunoglobulin G1 (IgG1) is a subclass of immunoglobulin that plays a crucial role in the immune response, particularly in recognizing and neutralizing pathogens. The specific compound you mentioned, anti-(human macrophage migration inhibitory factor) (MIF), is a human monoclonal antibody that targets MIF, a cytokine involved in inflammatory responses and immune regulation. The dimeric structure indicates that this antibody is formed by two linked chains: a γ1 heavy chain and a κ light chain, connected by disulfide bonds, which are essential for maintaining the stability and functionality of the antibody. This dimeric form enhances the binding affinity and specificity to its target, making it a valuable tool in therapeutic applications, particularly in conditions where MIF is implicated, such as autoimmune diseases and cancer. The CAS number 1430205-07-4 uniquely identifies this specific antibody, facilitating its recognition in scientific literature and regulatory contexts. Overall, this compound exemplifies the intricate design of monoclonal antibodies in targeting specific proteins for therapeutic interventions.

<p>A monoclonal antibody against macrophage inhibitory factor (MIF).</p>

Imalumab

<p>Imalumab (BAX69), a human IgG1 antibody, targets MIF for ovarian cancer, recurrent ascites, and cancer research.</p>

CAS 1430205-07-4

Immunoglobulin G1, anti-(human macrophage migration inhibitory factor) (human monoclonal BAX069 γ1-chain), disulfide with human monoclonal BAX069 κ-chain, dimer

Imalumab

Ref: 3D-CLA1366

Imalumab

Ref: TM-T76789