CAS 143113-45-5

6-21-Endothelin1 (swine reduced), N-acetyl-11-L-alanine-15-L-alanine-

Description:

6-21-Endothelin-1 (swine reduced), N-acetyl-11-L-alanine-15-L-alanine, with CAS number 143113-45-5, is a synthetic peptide that is a modified form of the naturally occurring endothelin-1, a potent vasoconstrictor involved in various physiological processes, including blood pressure regulation and vascular tone. This specific compound features structural modifications that enhance its stability and bioactivity compared to the native peptide. It is characterized by its amino acid sequence, which includes N-acetylation and specific L-alanine residues, contributing to its unique properties. The compound is typically studied for its role in cardiovascular research and potential therapeutic applications, particularly in conditions related to vascular dysfunction. Its synthesis and characterization involve techniques such as solid-phase peptide synthesis and analytical methods like mass spectrometry and high-performance liquid chromatography (HPLC) to confirm purity and identity. As a research tool, it aids in understanding the mechanisms of endothelin signaling and its implications in health and disease.

Formula: C₉₆H₁₄₀N₂₀O₂₅S

Synonyms:

• Endothelin1 (pig reduced), 1-de-L-cysteine-2-de-L-serine-3-de-L-cysteine-4-de-L-serine-5-de-L-serine-6-(N-acetyl-L-leucine)-11-L-alanine-15-L-alanine-
• Bq 3020
• Endothelin 1 (swine reduced),1-de-L-cysteine-2-de-L-serine-3-de-L-cysteine-4-de-L-serine-5-de-L-serine-6-(N-acetyl-L-leucine)-11-L-alanine-15-L-alanine-

BQ-3020

CAS: 143113-45-5

Formula: C₉₆H₁₄₀N₂₀O₂₅S

Molecular weight: 2006.32

Ref: 7W-GK9187

BQ-3020

CAS: 143113-45-5

Formula: C₉₆H₁₄₀N₂₀O₂₅S

Molecular weight: 2006.35

Ref: 4Z-PB-225001

Acetyl-(Ala11·15)-Endothelin-1 (6-21)

CAS: 143113-45-5

Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile
TrpOH is a recombinant peptide that is a potent endothelin receptor antagonist. It binds to the endothelin receptor, blocking the binding of endothelin and preventing activation of the receptor. Acetyl-(Ala11·15)-Endothelin (6–21) Ac has been shown to inhibit atrial natriuretic peptide levels and reduce blood pressure in experimental models. This drug also prevents balloon injury by blocking the binding of endothelin to its receptors and inhibits growth factor β1, which is an important mediator in pulmonary hypertension. The mechanism of action for this drug is not fully understood, but it may work through inhibiting

Formula: C₉₆H₁₄₀N₂₀O₂₅S

Purity: Min. 95%

Molecular weight: 2,006.32 g/mol

Ref: 3D-FA110316