CAS 143201-11-0

Rivastatin

Description:

Rivastatin, with the CAS number 143201-11-0, is a synthetic compound primarily classified as a statin, which is a class of drugs used to lower cholesterol levels in the blood. It functions by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in the biosynthesis of cholesterol. Rivastatin is characterized by its ability to reduce low-density lipoprotein (LDL) cholesterol and triglycerides while potentially increasing high-density lipoprotein (HDL) cholesterol. The compound is typically administered orally and is known for its favorable pharmacokinetic profile, including good absorption and metabolism. Rivastatin may also exhibit anti-inflammatory and antioxidant properties, contributing to cardiovascular health beyond cholesterol management. As with other statins, it may have side effects, including muscle pain and liver enzyme alterations, necessitating monitoring during treatment. Overall, rivastatin represents a significant therapeutic option in managing dyslipidemia and reducing the risk of cardiovascular diseases.

Formula: C₂₆H₃₄FNO₅

InChI: InChI=1/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1

InChI key: InChIKey=UVXVKMCFVDNBCD-QCVDVZFFSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=C(COC)C(C(C)C)=NC1C(C)C)C2=CC=C(F)C=C2.[Na]

Synonyms:

• (+)-Sodium (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoate
• 6-Heptanoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-(S-(R*,S*-(E)))-, sodium salt
• 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-
• 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (S-(R*,S*-(E)))-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, monosodium salt, [R-[R*,S*-(E)]]-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, sodium salt (1:1), (3R,5S,6E)-
• 7-(4-(4-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyrid-3-yl)-3,5-dihydroxy-6-heptenoate sodium salt
• Bay w 6228
• Baycol
• Lipobay
• Rivastatin
• Unii-6Q18G1060S
• sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate
• Cerivastatin sodium
• CERIVASTATIN
• Rivastatin, Baycol, Lipobay

Cerivastatin, Sodium Salt

CAS: 143201-11-0

Formula: C₂₆H₃₃FNNaO₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 481.5321

Ref: IN-DA007Z1N

Sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoate

CAS: 143201-11-0

Sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoate

Purity: 99%

Molecular weight: 481.54g/mol

Ref: 54-PC1007894

Cerivastatin Sodium Salt

CAS: 143201-11-0

Formula: C₂₆H₃₃FNO₅·Na

Color and Shape: White To Off-White Solid

Molecular weight: 458.56 22.99

Ref: 4Z-C-328001

Cerivastatin sodium salt hydrate

CAS: 143201-11-0

Formula: C₂₆H₃₃FNNaO₅·xH₂O

Purity: ≥ 97.0% (anhydrous basis)

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 481.53 (anhydrous)

Ref: 7W-GP6776

Cerivastatin-13C-d3 Sodium Salt

CAS: 143201-11-0

Formula: CC₂₅H₃₀D₃FNO₅·Na

Color and Shape: Off-White Solid

Molecular weight: 462.56 22.99

Ref: 4Z-C-328002

Cerivastatin sodium

CAS: 143201-11-0

Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.

Formula: C₂₆H₃₃FNNaO₅

Purity: 98.50% - 99.67%

Color and Shape: Solid

Molecular weight: 481.53

Ref: TM-T10767

Cerivastatin Sodium Salt

Controlled Product

CAS: 143201-11-0

Stability Hygroscopic
Applications Cerivastatin is a competitive inhibitor of HMG-CoA reductase.
References Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996), Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996),

Formula: C₂₆H₃₃FNO₅·Na

Color and Shape: White To Off-White

Molecular weight: 481.53

Ref: TR-C277000

Cerivastatin sodium - Bio-X ™

CAS: 143201-11-0

Cerivastatin is a drug that belongs to the class of drugs called statins. This drug is used to reduce the risk of cardiovascular events and lower lipid levels. Cerivastatin is an HMG-CoA reductase inhibitor and allows for a decrease in cholesterol in hepatic cells. Cerivastatin is cardioprotective and anti-atherosclerotic.

Formula: C₂₆H₃₃FNNaO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 481.53 g/mol

Ref: 3D-BC300049

Cerivastatin sodium

CAS: 143201-11-0

An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that reduces total cholesterol and low-density lipoprotein (LDL). Cerivastatin is cardioprotective and anti-atherosclerotic. Cerivastatin inhibits the expression of the atherosclerotic genes monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2), whilst inducing the expression of Kruppel-like factor 2 (KLF2).

Formula: C₂₆H₃₃FNNaO₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 481.53 g/mol

Ref: 3D-FC19906