(S)-Azelastine is a chiral compound primarily recognized for its application as an antihistamine, particularly in the treatment of allergic rhinitis and conjunctivitis. It belongs to the class of compounds known as phthalazinones and is characterized by its ability to selectively antagonize histamine H1 receptors, thereby alleviating allergy symptoms. The molecular structure of (S)-Azelastine features a phthalazine core, which contributes to its pharmacological properties. It exhibits a relatively high lipophilicity, allowing for effective penetration through biological membranes, which is beneficial for its therapeutic effects. Additionally, (S)-Azelastine has a long duration of action, making it suitable for once-daily dosing in clinical settings. The compound is typically administered in the form of nasal sprays or eye drops, providing localized relief with minimal systemic side effects. Its safety profile is generally favorable, although some patients may experience mild side effects such as drowsiness or local irritation. Overall, (S)-Azelastine represents a significant advancement in allergy management due to its efficacy and targeted action.

(S)-Azelastine

143228-85-7: (S)-Azelastine is a chiral compound primarily recognized for its application as an antihistamine, particularly in the treatment of allergic rhinitis and conjunctivitis. It belongs to the class of compounds known as phthalazinones and is characterized by its ability to selectively antagonize histamine H1 receptors, thereby alleviating allergy symptoms. The molecular structure of (S)-Azelastine features a phthalazine core, which contributes to its pharmacological properties. It exhibits a relatively high lipophilicity, allowing for effective penetration through biological membranes, which is beneficial for its therapeutic effects. Additionally, (S)-Azelastine has a long duration of action, making it suitable for once-daily dosing in clinical settings. The compound is typically administered in the form of nasal sprays or eye drops, providing localized relief with minimal systemic side effects. Its safety profile is generally favorable, although some patients may experience mild side effects such as drowsiness or local irritation. Overall, (S)-Azelastine represents a significant advancement in allergy management due to its efficacy and targeted action.

<p>(S)-Azelastine is an antihistamine reducing receptors H1R, M1R, M3R, and inhibiting HNEpC cell growth.</p>

CAS 143228-85-7

(S)-Azelastine

(S)-Azelastine

Ref: TM-T70674