CAS 143257-98-1

Lerisetron

Description:

Lerisetron is a chemical compound classified as a selective serotonin receptor antagonist, specifically targeting the 5-HT3 receptor. It is primarily investigated for its potential use in the treatment of gastrointestinal disorders, particularly those associated with nausea and vomiting, such as chemotherapy-induced nausea. The compound exhibits a high affinity for the 5-HT3 receptor, which plays a crucial role in the emetic response. Lerisetron's mechanism of action involves blocking serotonin's effects at these receptors, thereby reducing the sensation of nausea. In terms of its physical properties, Lerisetron is typically presented as a white to off-white solid, and its solubility characteristics allow for formulation in various pharmaceutical preparations. As with many pharmacological agents, the safety and efficacy profile of Lerisetron is evaluated through clinical trials, and it is essential to consider potential side effects and interactions with other medications. Overall, Lerisetron represents a significant area of research in the field of antiemetic therapies.

Formula: C₁₈H₂₀N₄

InChI: InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2

InChI key: InChIKey=PWWDCRQZITYKDV-UHFFFAOYSA-N

SMILES: C(N1C(=NC=2C1=CC=CC2)N3CCNCC3)C4=CC=CC=C4

Synonyms:

• 1-(Phenylmethyl)-2-(1-piperazinyl)-1H-benzimidazole
• 1-Benzyl-2-(1-piperazinyl)benzimidazole
• 1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole
• 1-benzyl-2-(piperazin-1-yl)-1H-benzimidazole
• 1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)-
• Lerisetron [INN]
• Unii-Q36R82Sxrg
• Lerisetron

1-benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole

CAS: 143257-98-1

Formula: C₁₈H₂₀N₄

Purity: 99%

Molecular weight: 292.3782

Ref: IN-DA009HVF

Lerisetron

CAS: 143257-98-1

Lerisetron

Purity: ≥98%

Molecular weight: 292.38g/mol

Ref: 54-BUP04372

Lerisetron

CAS: 143257-98-1

Purity: 98%

Molecular weight: 292.385986328125

Ref: 10-F601273

Lerisetron

CAS: 143257-98-1

Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.

Formula: C₁₈H₂₀N₄

Purity: 99.15% - 99.82%

Color and Shape: Solid

Molecular weight: 292.38

Ref: TM-T8441

1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole

CAS: 143257-98-1

1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole is a 5HT agonist that has been shown to stimulate the synthesis of collagen and α1 acid glycoprotein in human serum. It also has been shown to inhibit the growth of cancer cells in cell culture. This drug may have an effect on the production of fibrinogen, which is a protein involved in blood clotting. 1-Benzyl-2-(piperazin-1-yl)-1H-1,3 benzodiazole also binds to peptides and inhibits their binding to receptors on the surface of cells. The binding prevents the activation of these receptors by peptide ligands, which may lead to decreased levels of certain growth factors such as IGF or EGF.

Formula: C₁₈H₂₀N₄

Purity: Min. 95%

Molecular weight: 292.4 g/mol

Ref: 3D-TFA25798