CAS 143313-51-3

AC-YVAD-CHO

Description:

AC-YVAD-CHO is a synthetic peptide that serves as a selective inhibitor of caspase-1, an enzyme involved in the inflammatory response and apoptosis. This compound is characterized by its ability to block the activation of caspase-1, thereby modulating processes related to inflammation and cell death. The structure of AC-YVAD-CHO includes an acetyl group, which enhances its cell permeability, and a carbonyl group that is crucial for its inhibitory activity. It is commonly used in research settings to study the role of caspase-1 in various biological processes, including cytokine maturation and pyroptosis. The compound is typically utilized in in vitro experiments and has potential implications in therapeutic strategies for diseases characterized by excessive inflammation. As with many peptides, its stability and solubility can be influenced by environmental factors, and it is essential to handle it under appropriate laboratory conditions to maintain its integrity and efficacy.

Formula: C₂₃H₃₂N₄O₈

InChI: InChI=1/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1

SMILES: CC(C)[C@@H](C(=O)N=C([C@H](C)N[C@@H](CC(=O)O)C=O)O)N=C([C@H](Cc1ccc(cc1)O)N=C(C)O)O

Synonyms:

• N-Acetyl-L-Tyrosyl-L-Valyl-N-[(1S)-2-Carboxyl-1-Formylethyl]-L-Alaninamide
• N-Acetyl-Tyr-Val-Ala-Asp-Cho (Aldehyde)
• N-Acetyl-Tyr-Val-Ala-Glu-Al
• N-Ac-Tyr-Val-Ala-Asp-Cho
• N-Acetyl-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-Cho (Aldehyde)
• Tyr-Val-Ala-Asp-Cho
• Yvad-Cho
• Ice Inhibitor
• N-acetyl-L-tyrosyl-N-[(2S)-2-{[(1S)-2-carboxy-1-formylethyl]amino}propanoyl]-L-valinamide

Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

CAS: 143313-51-3

Ac-YVAD-CHO is a potent, specific, reversible inhibitor of caspase-1 (ICE). It displayed a Ki of 0.2 ± 0.1 nM for recombinant human caspase-1.

Formula: C₂₃H₃₂N₄O₈

Purity: > 95%

Color and Shape: White

Molecular weight: 492.53

Ref: 01-4018830

Caspase-1 Inhibitor I

CAS: 143313-51-3

Formula: C₂₃H₃₂N₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 492.5222

Ref: IN-DA007YY8

Ac-YVAD-CHO

CAS: 143313-51-3

Ac-YVAD-CHO

Purity: ≥95%

Molecular weight: 492.52g/mol

Ref: 54-BUP00600

Ac-YVAD-CHO

CAS: 143313-51-3

Ac-YVAD-CHO (L 709049) is an ICE and caspase-1-like protease inhibitor with anti-inflammatory activity that inhibits the production of mature IL-lβ.

Formula: C₂₃H₃₂N₄O₈

Purity: 96.49%

Color and Shape: Solid

Molecular weight: 492.52

Ref: TM-T19883

Ac-Tyr-Val-Ala-Asp-H (aldehyde)

CAS: 143313-51-3

Ac-Tyr-Val-Ala-Asp-H (aldehyde) is a peptide that inhibits the activity of protein tyrosine phosphatases, which are enzymes that remove phosphate groups from proteins. This agent binds to the amino acid side chains of an enzyme and prevents it from binding to its substrate. Ac-Tyr-Val-Ala-Asp-H (aldehyde) is a research tool that can be used in life sciences as an inhibitor or activator for peptides, receptors, and ion channels. Ac-Tyr-Val-Ala-Asp-H (aldehyde) has been shown to be active in the inhibition of protein tyrosine phosphatase 1B and 2A isoforms.

Formula: C₂₃H₃₂N₄O₈

Purity: Min. 95%

Molecular weight: 492.52 g/mol

Ref: 3D-IAT-3165-V

Caspase-1 Inhibitor I

Controlled Product

CAS: 143313-51-3

Formula: C₂₃H₃₂N₄O₈

Color and Shape: Neat

Molecular weight: 492.522

Ref: TR-C184910

Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

CAS: 143313-51-3

Ac-Tyr-Val-Ala-Asp-aldehyde is a sesquiterpene lactone that has been shown to have anti-inflammatory properties. It inhibits the inflammatory response by inhibiting the production of pro-inflammatory cytokines and chemokines, such as IL1β, IL6, and TNFα. Ac-Tyr-Val-Ala-Asp-aldehyde also inhibits the activity of cyclooxygenase 2 (COX2) and lipoxygenase (LOX), which are enzymes that produce prostaglandins from arachidonic acid. Acetylsalicylic acid is an example of a drug with similar properties. Acetylsalicylic acid has been shown to inhibit the growth of cancer cells in tissue culture studies and in animal models. This compound may also be used to treat bowel disease, congestive heart failure, or other diseases that are characterized by increased apoptosis.

Formula: C₂₃H₃₂N₄O₈

Purity: Min. 95%

Molecular weight: 492.52 g/mol

Ref: 3D-FA110311