CAS 1433497-19-8

LY2955303

CAS: 1433497-19-8

LY2955303

Purity: ≥98%

Molecular weight: 578.74g/mol

Ref: 54-BUP01346

LY2955303

Controlled Product

CAS: 1433497-19-8

Formula: C₃₆H₄₂N₄O₃

Color and Shape: Neat

Molecular weight: 578.744

Ref: TR-L490020

LY2955303

CAS: 1433497-19-8

LY2955303 is a synthetic retinoid that has been shown to be effective in the treatment of pancreatic cancer. LY2955303 acts by binding to all-trans retinoic acid receptors, which are expressed on the surface of cancer cells. This drug binds to the receptor and inhibits proliferation and induces apoptosis in pancreatic cancer cells. LY2955303 also inhibits esophageal adenocarcinoma cell proliferation, as well as inducing apoptosis via the same mechanism. The crystal structure of LY2955303 bound to an all-trans retinoic acid receptor has been determined using X-ray crystallography. The structure reveals that this drug interacts with a hydrophobic pocket on the surface of the receptor, preventing it from activating transcription factors inside the cell nucleus. LY2955303 also has pharmacokinetic properties similar to those of other retinoids, with a rapid absorption rate that is followed by a slow elimination phase.

Formula: C₃₆H₄₂N₄O₃

Purity: Min. 95%

Molecular weight: 578.74 g/mol

Ref: 3D-IHC49719

LY2955303

CAS: 1433497-19-8

LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).

Formula: C₃₆H₄₂N₄O₃

Purity: 98.56% - 99.85%

Color and Shape: Solid

Molecular weight: 578.74

Ref: TM-T15811