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CAS 143491-54-7

:

2',3'-dideoxy-5-fluoro-3'-thiacytidine

Description:
2',3'-Dideoxy-5-fluoro-3'-thiacytidine, also known by its CAS number 143491-54-7, is a synthetic nucleoside analog that exhibits antiviral properties, particularly against certain viruses such as HIV. This compound is characterized by the presence of a sulfur atom in the ribose ring, replacing the oxygen typically found in nucleosides, which contributes to its unique biochemical properties. The fluorine substitution at the 5-position of the pyrimidine ring enhances its stability and bioactivity. As a dideoxynucleoside, it lacks the hydroxyl groups at the 2' and 3' positions, which is crucial for its mechanism of action, as it inhibits viral replication by terminating the elongation of the viral DNA chain during reverse transcription. This compound is of interest in medicinal chemistry and virology for its potential therapeutic applications, although its use may be limited by factors such as toxicity and resistance development in viral strains. Overall, 2',3'-dideoxy-5-fluoro-3'-thiacytidine represents a significant area of research in antiviral drug development.
Formula:C8H10FN3O3S
InChI:InChI=1/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1
Synonyms:
  • Racivir
  • 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
  • 2',3',5-Ftc
  • 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, cis-
  • 3'-Thia-2'.3'-dideoxy-5-fluorocytidine
  • 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
  • 524W91
  • Bw 524W91
  • RCV
  • 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, rel-
  • See more synonyms
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