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CAS 143621-35-6

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Triapine

Description:
Triapine, with the CAS number 143621-35-6, is a chemical compound known for its role as an inhibitor of ribonucleotide reductase, an enzyme critical for DNA synthesis and repair. It is classified as a pyrimidine derivative and has been investigated primarily for its potential use in cancer therapy, particularly in combination with other chemotherapeutic agents. Triapine exhibits characteristics such as being a white to off-white solid, and it is soluble in various organic solvents. Its mechanism of action involves the depletion of deoxyribonucleotide triphosphates, which can lead to the inhibition of tumor cell proliferation. Additionally, Triapine has shown promise in preclinical studies and clinical trials, although its clinical application is still under investigation. Safety and efficacy profiles are essential considerations in its development, as with any therapeutic agent. Overall, Triapine represents a significant area of research in the field of oncology, particularly in the context of enhancing the effectiveness of existing cancer treatments.
Formula:C7H9N5S
InChI:InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)
InChI key:InChIKey=XMYKNCNAZKMVQN-UHFFFAOYSA-N
SMILES:C(=NNC(N)=S)C1=C(N)C=CC=N1
Synonyms:
  • (2E)-2-[(3-aminopyridin-2-yl)methylidene]hydrazinecarbothioamide
  • 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
  • 3-Aminopyridine-2-Carbaldehyde Thiosemicarbazone
  • Aids-179996
  • Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-
  • NSC 663249
  • Ocx 0191
  • Ocx 191
  • Pan 811
  • Triapine
  • See more synonyms
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Found 4 products.