CAS 14365-45-8

2'-DEOXY-B-L-ADENOSINE

Description:

2'-Deoxy-B-L-adenosine, with the CAS number 14365-45-8, is a nucleoside that plays a crucial role in biochemistry, particularly in the structure of DNA. It consists of a deoxyribose sugar moiety linked to the purine base adenine. This compound is characterized by its ability to participate in the formation of nucleic acids, serving as a building block for DNA synthesis. The absence of a hydroxyl group at the 2' position of the sugar distinguishes it from ribonucleosides, making it integral to the stability and function of DNA. In terms of solubility, 2'-deoxy-B-L-adenosine is typically soluble in water, which facilitates its biological functions. It is also involved in various metabolic pathways and can be phosphorylated to form deoxyadenosine triphosphate (dATP), a critical energy carrier and substrate in DNA replication and repair processes. Overall, 2'-deoxy-B-L-adenosine is essential for genetic information storage and transmission in living organisms.

Formula: C₁₀H₁₃N₅O₃

InChI: InChI=1/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6-,7-/m0/s1

Synonyms:

• 9-(2-deoxy-beta-L-threo-pentofuranosyl)-9H-purin-6-amine

(2S,3R,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

CAS: 14365-45-8

Formula: C₁₀H₁₃N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 251.2419

Ref: IN-DA007JP6

2''-Deoxy-L-adenosine

CAS: 14365-45-8

Ref: 7W-GN6479

9-(2-Deoxy-β-L-Ribofuranosyl)Adenine

CAS: 14365-45-8

9-(2-Deoxy-β-L-Ribofuranosyl)Adenine

Purity: 98%

Molecular weight: 251.24g/mol

Ref: 54-OR1012110

2'-Deoxy-beta-L-adenosine

Controlled Product

CAS: 14365-45-8

Applications A useful synthon for modified oligodeoxyribonucleotides.
References Fujimori, S., et al.: Nucleoside & Nucleotide, 11(2-4), 341 (1992)

Formula: C₁₀H₁₃N₅O₃

Color and Shape: Neat

Molecular weight: 251.24

Ref: TR-D231625

2’-Deoxy-β-L-adenosine (May contain up to 20% inorganics)

Controlled Product

CAS: 14365-45-8

Formula: C₁₀H₁₃N₅O₃

Color and Shape: Neat

Molecular weight: 251.24

Ref: TR-D231628

2-Deoxy-B-L-adenosine

CAS: 14365-45-8

Formula: C₁₀H₁₃N₅O₃

Molecular weight: 251.25

Ref: ST-EA-CP-A88056

2'-Deoxy-L-adenosine

CAS: 14365-45-8

2'-Deoxy-L-adenosine is an adenosine analogue that has been shown to inhibit the growth of tumor cells in mice. The mechanism of this inhibition is not well understood, but it is thought that 2'-deoxy-L-adenosine inhibits the adenosine A3 receptor and blocks the activation of toll-like receptors. This drug also has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. It has been used as a model system for studying cellular responses to DNA damage caused by ultraviolet radiation. 2'-Deoxy-L-adenosine also has been shown to have a cytotoxic effect on human HL60 cells, which is mediated by nuclear DNA fragmentation.

Formula: C₁₀H₁₃N₅O₃

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 251.25 g/mol

Ref: 3D-ND04246