CAS 143748-18-9

Pituitary Adenylate Cyclase Activating Polypeptide (6-38) amide (human, ovine, rat)

Description:

Pituitary Adenylate Cyclase Activating Polypeptide (6-38) amide, often abbreviated as PACAP (6-38), is a peptide fragment derived from the larger PACAP molecule, which plays a crucial role in various physiological processes. This specific fragment is known for its ability to modulate adenylate cyclase activity, influencing intracellular signaling pathways. It is characterized by its structure, which consists of a sequence of amino acids that contribute to its biological activity. The amide form indicates that the terminal amino group is modified, enhancing its stability and bioactivity. PACAP (6-38) has been studied for its neuroprotective effects, involvement in neuroendocrine regulation, and potential roles in various neurological disorders. Its interactions with specific receptors, such as PACAP receptors, are essential for mediating its effects in the central nervous system and peripheral tissues. The CAS number 143748-18-9 uniquely identifies this compound in chemical databases, facilitating research and application in pharmacology and biochemistry. Overall, PACAP (6-38) amide is a significant peptide in the study of neurobiology and therapeutic development.

Formula: C₁₈₂H₃₀₀N₅₆O₄₅S

Synonyms:

• H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat)

CAS: 143748-18-9

The PACAP selective antagonist PACAP (6-38) is a potent and selective inhibitor of PACAP-27-stimulated pituitary adenylate cyclase with a Ki values of 150 nM.

Formula: C₁₈₂H₃₀₀N₅₆O₄₅S

Purity: 97.3%

Color and Shape: White

Molecular weight: 4024.8

Ref: 01-4031158

H-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2

CAS: 143748-18-9

Formula: C₁₈₂H₃₀₀N₅₆O₄₅S

Purity: 95%

Molecular weight: 4024.7426

Ref: IN-DA00AP41

PACAP (6-38), human, ovine, rat

CAS: 143748-18-9

PACAP (6-38) in humans, sheep, rats: a strong inhibitor of PACAP 38, outperforms PACAP (6-27) in blocking PACAP-27-induced adenylate cyclase.

Formula: C₁₈₂H₃₀₀N₅₆O₄₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 4024.74

Ref: TM-TP1722

PACAP (Human, 6-38)

CAS: 143748-18-9

PACAP is a peptide that belongs to the class of activators. It is used as a research tool for its ability to activate ion channels in mammalian cells. PACAP interacts with receptors and can be found in both the central nervous system and peripheral tissues. The receptor for PACAP, known as the PAC1 receptor, is coupled to G-proteins and regulates adenylate cyclase activity. PACAP has been shown to inhibit cell proliferation and promote apoptosis in various types of cancer cells.
PACAP also stimulates the release of oxytocin from neurohypophysis cells, which may lead to its use as a treatment for autism spectrum disorders or depression.

Formula: C₁₈₂H₃₀₀N₅₆O₄₅S

Purity: Min. 95%

Molecular weight: 4,024.7 g/mol

Ref: 3D-PPA-4286-V

PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat) trifluoroacetate salt

CAS: 143748-18-9

Please enquire for more information about PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₈₂H₃₀₀N₅₆O₄₅S

Purity: Min. 95%

Molecular weight: 4,024.75 g/mol

Ref: 3D-FP108759