CAS 143782-20-1

4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile

Description:

4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile, with CAS number 143782-20-1, is a synthetic organic compound characterized by its complex molecular structure, which includes an imidazolidine ring and a trifluoromethyl group. This compound typically exhibits properties such as high stability due to the presence of the dioxo functional groups, which can influence its reactivity and solubility in various solvents. The trifluoromethyl group enhances lipophilicity and can affect the compound's biological activity, making it of interest in pharmaceutical applications. Additionally, the presence of the benzonitrile moiety suggests potential uses in organic synthesis and as an intermediate in the production of other chemical entities. Its unique structure may also impart specific electronic properties, making it suitable for various applications in materials science and medicinal chemistry. Overall, this compound represents a versatile building block in the development of novel chemical products.

Formula: C₁₃H₁₀F₃N₃O₂

InChI: InChI=1S/C13H10F3N3O2/c1-12(2)10(20)19(11(21)18-12)8-4-3-7(6-17)9(5-8)13(14,15)16/h3-5H,1-2H3,(H,18,21)

InChI key: InChIKey=CYCKLVAQENOQPG-UHFFFAOYSA-N

SMILES: O=C1N(C(=O)NC1(C)C)C2=CC(C(F)(F)F)=C(C#N)C=C2

Synonyms:

• RU 56279
• 4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile
• Benzonitrile, 4-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)-
• 4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile

4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile

CAS: 143782-20-1

Formula: C₁₃H₁₀F₃N₃O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 297.2326

Ref: IN-DA0039Z4

4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile

CAS: 143782-20-1

4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile

Purity: 95%

Molecular weight: 297.24g/mol

Ref: 54-PC1007417

4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile

Controlled Product

CAS: 143782-20-1

Applications 4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile is an intermediate in the synthesis of Oxo-MDV 3100 (Oxo-enzalutamide) (O857800), which is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);

Formula: C₁₃H₁₀F₃N₃O₂

Color and Shape: Neat

Molecular weight: 297.23

Ref: TR-D143780

4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile

CAS: 143782-20-1

Formula: C₁₃H₁₀F₃N₃O₂

Purity: 95%

Molecular weight: 297.237

Ref: 10-F433621