CAS 1438071-12-5

N-[(4-Chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-2-thiophenemethanamine

Description:

N-[(4-Chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-2-thiophenemethanamine, identified by its CAS number 1438071-12-5, is a synthetic organic compound characterized by its complex structure, which includes a thiophene ring, nitro group, and multiple chlorinated phenyl moieties. The presence of the nitro group suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, as nitro compounds often exhibit biological activity. The chlorinated phenyl groups may enhance lipophilicity and influence the compound's interaction with biological targets. Additionally, the thiophene ring contributes to the compound's electronic properties and stability. This compound's specific characteristics, such as solubility, melting point, and reactivity, would depend on its molecular interactions and the environment in which it is studied. As with many synthetic compounds, safety and handling precautions are essential, given the potential toxicity associated with nitro and chlorinated compounds. Further research would be necessary to fully elucidate its properties and potential applications in various fields.

Formula: C₂₀H₁₈Cl₂N₂O₂S

InChI: InChI=1S/C20H18Cl2N2O2S/c1-14-10-18(22)7-4-16(14)12-23(11-15-2-5-17(21)6-3-15)13-19-8-9-20(27-19)24(25)26/h2-10H,11-13H2,1H3

InChI key: InChIKey=NXCSEAQOKPSNJV-UHFFFAOYSA-N

SMILES: N(CC=1SC(N(=O)=O)=CC1)(CC2=C(C)C=C(Cl)C=C2)CC3=CC=C(Cl)C=C3

Synonyms:

• N-[(4-Chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-2-thiophenemethanamine
• N-(4-Chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
• GSK 2945
• 2-Thiophenemethanamine, N-[(4-chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-
• BJ 16

GSK2945

CAS: 1438071-12-5

GSK2945 is a potent and selective activator of the human TRPA1 ion channel. It shows no cytotoxicity at concentrations up to 1 μM. GSK2945 binds to the extracellular domain of TRPA1, activating the channel by increasing its open probability. GSK2945 has been shown to be selective for TRPA1 over TRPV1, TRPM8, and other ion channels.

Formula: C₂₀H₁₈Cl₂N₂O₂S

Purity: Min. 95%

Molecular weight: 421.3 g/mol

Ref: 3D-NHC07112

GSK2945

CAS: 1438071-12-5

GSK2945, a specific Rev-erbα antagonist, boosts CYP7A1 and cholesterol metabolism. EC50: 21.5 μM (mouse), 20.8 μM (human).

Formula: C₂₀H₁₈Cl₂N₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 421.34

Ref: TM-T11490